Research Tools Conformation-Specific Genetically Encodable Intrabodies for Spatially Modulating Protein Kinase Signaling Genetically encoded synthetic antibody fragments, expressed intracellularly, to specifically bind the mTOR FKBP12-Rapamycin binding domain inhibiting mTORC1 and mTORC2 activity. Fused with localization signals,… Interests: Antibody, Drug Development Tool Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Technology Classifications Therapeutics Bioorthogonal Enzyme-Probe System For Spatially Specific Biomolecule Labeling Novel proximity labeling technology utilizes a bioorthogonal protecting group, impervious to endogenous esterases, paired with evolved BS2 esterase mutants. The enzyme-mediated unmasking creates a… Interests: Drug Development Tool Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for… Interests: Biologics, Gene Therapy, Infectious Disease, Tangible Property Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Context-Specific Cytosine Base Editors For Precise Single-Nucleotide DNA Editing Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with… Interests: Cell Line, Drug Development Tool, Gene Therapy Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Antibody-Based Therapeutics For Inhibiting Growth Hormone Receptor Dimerization And Signaling Antibodies that block growth hormone signaling by binding the receptor or hormone to stop receptor pairing, based on high-affinity, defined sequences for therapeutic and… Interests: Antibody, Rare/Orphan Diseases Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Pan-Specific γ9δ2 T-Cell Antibodies For Activation And Targeted Cancer Immunotherapy A panel of pan-specific Vγ9Vδ2 TCR-recognizing antibodies that allosterically trigger T-cell activation to engage and kill cancer cells, making it highly applicable for targeted… Interests: Antibody, Antibody, Immunotherapy Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Single-Step Method For Assembling Free-Standing Lipid Bilayers In Holey Grids For Cryo-EM Of Membrane Proteins Simplified approach to assemble free-standing lipid bilayers with membrane proteins in holey carbon grids directly usable for cryo-EM with high resolution The Unmet… Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Research Tools Therapeutics Scalable Bioelectronic Production Of Extracellular Vesicles For Regenerative Medicine Bioelectronic devices and methods for the electrical stimulation of cells and engineered tissue for the scalable production of extracellular vesicles for drug delivery and… Interests: Medical, Stem Cell Therapy Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase A novel platform, bacterial deaminase-enabled recoding of RNA (DECOR), utilizing an engineered bacterial adenosine deaminase to achieve programmable adenosine-to-inosine (A-to-I) editing on single-stranded RNA.… Interests: Gene Therapy Desired Partnership: Co-development, Licensing IP: Patent Pending
Medical Devices Research Tools New Toolkit And Methods For Large-Scale Spatial Transcriptomics Tools and methods to map the entire transcriptome with large-scale histology sections from whole animal or whole human organs with high resolution and sensitivity… Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Novel In Vivo Gene Editing System A engineered OgeuIscB- ωRNA for efficient and precise genome editing with increased potency and specificity while more compact in size compared to other CRISPR-Cas… Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Genetic Engineering Tools To Stimulate And Enhance The Production Of Select Compounds From Bacterial Species Synthetic biology toolsets to genetically manipulate the microbiota, specifically non-model resident gut microbes, to alter gene expression and cellular function to produce therapeutic compounds.… Interests: Gastrointestinal, Immunology, Inflammatory, Metabolic Disorders, Microbiome Desired Partnership: Co-development, Licensing IP: Patent Pending
