Quantum Sciences Research Tools Probing Cellular Activity Via Charge-Sensitive Quantum Nanoprobes Quantum nanoprobe system enables real-time probing of intracellular chemical environments and activity to advance biological and medical diagnostics The Unmet Need: Novel ways to… Interests: Drug Development Tool, Drug Screening, Sensing Reference ID: 25-T-106 Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Research Tools A High-Throughput, Label-Free Microfluidic System For Combinatorial Droplet Generation, Storage, And Analysis A microfluidic platform consisting of a two-layer PDMS system that generates and stores combinatorial droplets, enabling high-throughput screening with an integrated label-free, image-based detection… Reference ID: 25-T-014 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Conformation-Specific Genetically Encodable Intrabodies for Spatially Modulating Protein Kinase Signaling Genetically encoded synthetic antibody fragments, expressed intracellularly, to specifically bind the mTOR FKBP12-Rapamycin binding domain inhibiting mTORC1 and mTORC2 activity. Fused with localization signals,… Interests: Antibody, Drug Development Tool Reference ID: 25-T-060 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Bioorthogonal Enzyme-Probe System For Spatially Specific Biomolecule Labeling Novel proximity labeling technology utilizes a bioorthogonal protecting group, impervious to endogenous esterases, paired with evolved BS2 esterase mutants. The enzyme-mediated unmasking creates a… Interests: Drug Development Tool Reference ID: 25-T-114 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for… Interests: Biologics, Gene Therapy, Infectious Disease, Tangible Property Reference ID: 25-T-198 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Context-Specific Cytosine Base Editors For Precise Single-Nucleotide DNA Editing Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with… Interests: Cell Line, Drug Development Tool, Gene Therapy Reference ID: 24-T-089 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Antibody-Based Therapeutics For Inhibiting Growth Hormone Receptor Dimerization And Signaling Antibodies that block growth hormone signaling by binding the receptor or hormone to stop receptor pairing, based on high-affinity, defined sequences for therapeutic and… Interests: Antibody, Rare/Orphan Diseases Reference ID: 23-T-100 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Pan-Specific γ9δ2 T-Cell Antibodies For Activation And Targeted Cancer Immunotherapy A panel of pan-specific Vγ9Vδ2 TCR-recognizing antibodies that allosterically trigger T-cell activation to engage and kill cancer cells, making it highly applicable for targeted… Interests: Antibody, Antibody, Immunotherapy Reference ID: 24-T-215 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Single-Step Method For Assembling Free-Standing Lipid Bilayers In Holey Grids For Cryo-EM Of Membrane Proteins Simplified approach to assemble free-standing lipid bilayers with membrane proteins in holey carbon grids directly usable for cryo-EM with high resolution The Unmet… Reference ID: 24-T-177 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Research Tools Therapeutics Scalable Bioelectronic Production Of Extracellular Vesicles For Regenerative Medicine Bioelectronic devices and methods for the electrical stimulation of cells and engineered tissue for the scalable production of extracellular vesicles for drug delivery and… Interests: Medical, Stem Cell Therapy Reference ID: 23-T-048 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase A novel platform, bacterial deaminase-enabled recoding of RNA (DECOR), utilizing an engineered bacterial adenosine deaminase to achieve programmable adenosine-to-inosine (A-to-I) editing on single-stranded RNA.… Interests: Gene Therapy Reference ID: 24-T-189 Desired Partnership: Co-development, Licensing IP: Patent Pending
Medical Devices Research Tools New Toolkit And Methods For Large-Scale Spatial Transcriptomics Tools and methods to map the entire transcriptome with large-scale histology sections from whole animal or whole human organs with high resolution and sensitivity… Reference ID: 22-T-069 Desired Partnership: Co-development, Licensing IP: Patent Pending
