Tangible Property

Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision

SUMMARY The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for synthetic biology and gene therapy. The ability to precisely modify DNA sequences within living cells is crucial… Read More

A Versatile and High-throughput Assay for the Directed Evolution of Reverse Transcriptases to Profile Epigenetic Modifications With NGS

SUMMARY Engineered reverse transcriptases (RTs) to profile epigenetic modifications have numerous advantages over traditional antibody enrichment methods including: single base pair resolution, lower sample quantities needed, and lower noise and background interference. Problematically, current RT engineering strategies are cumbersome, low throughput, and cannot be versatilely applied to multiple types of… Read More