SUMMARY Inrich-seq is a new method that selectively enriches and sequences inosine-containing DNA or RNA, enabling highly sensitive, genome-wide detection of off-target effects from adenine base editing in human cells The Unmet Need: Techniques need to rigorously evaluate and profile any unintended… Read More
SUMMARY A matched pair of photoproximity probes coupled with quantitative proteomics which enable context-dependent mapping of protein complex topology inside cells including to map MYC interactomes across temporal, spatial and disease-relevant contexts The Unmet Need: The ability to map… Read More
SUMMARY Quantum nanoprobe system enables real-time probing of intracellular chemical environments and activity to advance biological and medical diagnostics The Unmet Need: Novel ways to probe cellular processes and improve biological sensing Understanding complex cellular processes in real-time at the single-cell level… Read More
SUMMARY The field of oncological diagnostics and therapeutics has long sought methods to refine treatment approaches for aggressive cancers. In conditions such as advanced high-grade ovarian cancer, there is a critical need for techniques that can accurately predict therapeutic responses and guide personalized treatment decisions. This is driven by the… Read More
SUMMARY TB bacterium, Mycobacterium tuberculosis (M. tuberculosis), is extremely slow growing compared to other bacteria and is naturally resistant to many of the powerful antibiotics that are effective against other bacterial infections. In recent years, multi-drug-resistant TB strains (MDR-TB) have arisen that are resistant to standard treatment and require extensive… Read More
SUMMARY There is a limited choice in clinically approved adjuvants for vaccine development. Current solutions are themselves immunogenic, causing injection site swelling and reactions. The inventors developed a 15 amino acid peptide adjuvant (Q11) that forms a highly homogeneous network of laterally assembled beta sheet fivers in aqueous solution. When… Read More
SUMMARY Approximately 1/5 of antibiotic resistant infections in humans can be traced back to food and animals. The incidence of these infections is perpetuated by the widespread prophylactic use of antibiotics on farms. As such, there is an urgent need for alternative methods of preventing bacterial infection in livestock. It… Read More
SUMMARY Optimized small-molecule inhibitors of RAD51 that selectively suppress D-loop formation and homologous recombination The Unmet Need: Selective agents that suppress homologous recombination repair without off-target toxicity. RAD51 is a central protein in homologous recombination, a DNA repair pathway that helps cells repair double-strand breaks accurately. Many tumors overexpress RAD51… Read More
SUMMARY Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application is presently limited by a lack of deformability and degradability. The inventors developed a novel amorphous silicon material that retains all the advantageous properties of… Read More
SUMMARY An understanding of protein-protein interactions (PPIs) is critical to uncovering new disease pathophysiology and for developing small molecule and antibody treatments. Problematically, current approaches to assay PPIs are limited by sensitivity, signal to noise ratio, and the need to carefully optimize the assay for each new application. The inventors… Read More
SUMMARY Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation, the regulation of the enzymes that control it is poorly understood. The inventors designed an enzyme substrate analogue probe… Read More
SUMMARY Staphylococcus aureus infects 50,000 patients and kills 20,000 annually in the United States alone. With widespread antibiotic resistance, there is an urgent need for alternative mechanisms of targeting S. aureus infection. One way the pathogen mediates its virulence is by secreting the pore-forming cytotoxin α-hemolysin, which causes skin and… Read More