SUMMARY Inrich-seq is a new method that selectively enriches and sequences inosine-containing DNA or RNA, enabling highly sensitive, genome-wide detection of off-target effects from adenine base editing in human cells The Unmet Need: Techniques need to rigorously evaluate and profile any unintended… Read More
SUMMARY A matched pair of photoproximity probes coupled with quantitative proteomics which enable context-dependent mapping of protein complex topology inside cells including to map MYC interactomes across temporal, spatial and disease-relevant contexts The Unmet Need: The ability to map the… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY The field of oncological diagnostics and therapeutics has long sought methods to refine treatment approaches for aggressive cancers. In conditions such as advanced high-grade ovarian cancer, there is a critical need for techniques that can accurately predict therapeutic responses and guide personalized treatment decisions. This is driven by the… Read More
SUMMARY TB bacterium, Mycobacterium tuberculosis (M. tuberculosis), is extremely slow growing compared to other bacteria and is naturally resistant to many of the powerful antibiotics that are effective against other bacterial infections. In recent years, multi-drug-resistant TB strains (MDR-TB) have arisen that are resistant to standard treatment and require extensive… Read More
SUMMARY There is a limited choice in clinically approved adjuvants for vaccine development. Current solutions are themselves immunogenic, causing injection site swelling and reactions. The inventors developed a 15 amino acid peptide adjuvant (Q11) that forms a highly homogeneous network of laterally assembled beta sheet fivers in aqueous solution. When… Read More
SUMMARY Approximately 1/5 of antibiotic resistant infections in humans can be traced back to food and animals. The incidence of these infections is perpetuated by the widespread prophylactic use of antibiotics on farms. As such, there is an urgent need for alternative methods of preventing bacterial infection in livestock. It… Read More
SUMMARY The Rad51 enzyme is over-expressed in many cancers and promotes chemotherapy and radiation resistance by facilitating the homologous recombination necessary for DNA lesion repair. Current therapies that target RAD51 are plagued by significant off-target effects and toxicity. Current RAD51 inhibitors block the enzyme’s role in oncogenic homologous recombination, but… Read More
SUMMARY Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application is presently limited by a lack of deformability and degradability. The inventors developed a novel amorphous silicon material that retains all the advantageous properties of… Read More
SUMMARY Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation, the regulation of the enzymes that control it is poorly understood. The inventors designed an enzyme substrate analogue probe… Read More
SUMMARY Staphylococcus aureus infects 50,000 patients and kills 20,000 annually in the United States alone. With widespread antibiotic resistance, there is an urgent need for alternative mechanisms of targeting S. aureus infection. One way the pathogen mediates its virulence is by secreting the pore-forming cytotoxin α-hemolysin, which causes skin and… Read More
SUMMARY kV radiation dose for imaging tumors is useful for direct monitoring and real-time organ tracking without relying on high-risk surgical implants. However, the utility of this approach is limited by concerns of radiation overdose associated with exposing patients to an additional radiation source other than the MV treatment dose. Read More