SUMMARY A chemical process that enables reversible, covalent RNA modification-highly selective for uridine enabling diverse functional group attachment, facilitating nucleic acid labeling The Unmet Need: Reversible labeling of native RNA in a sequence-independent and membrane-selective manner … Read More
SUMMARY Despite the many advances in the field of resuscitation post cardiac arrest, hypoxic-ischemic brain injury (HIBI) leaves many survivors with severe neurological disability. Patients who remain comatose at 24–72 h or more after resuscitation undergo neuroprognostication, aimed to detect signs… Read More
SUMMARY Cancer cells show alterations in metabolism that support malignancy and disease progression. Prominent among these metabolic changes is elevations in neutral ether lipids (NELs). The lipid hydrolase neutral cholesterol ester hydrolase 1 (NCEH1), also known as AADACL1 or KIAA1363, has been shown to control the production of NELs in… Read More
SUMMARY Current high throughput assays to quantify radiation induced DNA damage are limited by low sensitivity and cannot reliably detect radiation induced damage lower than 10Gy (J/Kg), despite the fact that doses as low as 0.5Gy can confer elevated cancer risk. Improved assays are highly desirable to triage patients exposed… Read More
SUMMARY The targeted metabolic imaging enhancement achieved by deoxyglucose-labeled gold nanoparticles (AuNP-DG) offers superior tumor-specific contrast and improved resolution in computed tomography (CT) scans compared to conventional iodine-based agents, facilitating enhanced cancer diagnosis and treatment planning. The Unmet Need: Current CT contrast agents lack tumor-specific uptake and sustained imaging performance Traditional… Read More