SUMMARY Lentiviral display platform engineered to directly select and enrich antibodies based on their ability to induce receptor-mediated endocytosis, thereby streamlining the discovery of highly internalizing candidates for targeted therapies The Unmet Need: Efficient discovery platforms that directly select internalizing antibodies for… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY As of February 2021, there have been over 107 million cases and over 2 million deaths caused worldwide by the novel virus SARS-CoV-2. Few vaccination and treatment approaches are currently in use with many in development. The inventors isolated antibodies specific… Read More
SUMMARY Using recombinant antibody libraries for drug development has numerous advantages over animal immunization including: faster production times, favorable expression, and not being limited by antigen immunogenicity. However, this approach is limited by the significant effort and resources required to generate such a library. The inventors developed a novel 10^10… Read More
SUMMARY Antibody fragments such as Fabs have demonstrated their utility as research tools, diagnostics, and in therapeutic applications. However, the monovalent nature of Fabs and lack of avidity is particularly limiting for binding antigens at low concentration. The inventors engineered protein G to have higher affinity and specificity for Fabs… Read More