SUMMARY Lentiviral display platform engineered to directly select and enrich antibodies based on their ability to induce receptor-mediated endocytosis, thereby streamlining the discovery of highly internalizing candidates for targeted therapies The Unmet Need: Efficient discovery platforms that directly select internalizing antibodies for… Read More
SUMMARY Novel antibodies to rapidly and safely expand γδ T cells enabling large-scale production for cancer immunotherapies like γδ CAR-T cells, and potentially boosting these cells directly in patients The Unmet Need: Efficient large-scale expansion of γδ T cells with enhanced… Read More
SUMMARY Genetically encoded synthetic antibody fragments, expressed intracellularly, to specifically bind the mTOR FKBP12-Rapamycin binding domain inhibiting mTORC1 and mTORC2 activity. Fused with localization signals, these tools enable precise, compartment-specific modulation of mTOR signaling for research and therapeutic exploration The Unmet Need:… Read More
SUMMARY A panel of pan-specific Vγ9Vδ2 TCR-recognizing antibodies that allosterically trigger T-cell activation to engage and kill cancer cells, making it highly applicable for targeted cancer therapy. The Unmet Need: Strategy to safely and effectively harness Vγ9Vδ2 T cells for immunotherapeutic interventions… Read More
SUMMARY Cell division is a fundamental biological process, ensured to be of high fidelity by the Chromosome Passenger Complex (CPC), a crucial protein complex involved in regulating various chromosomal and cytoskeletal activities. The CPC, composed of survivin, borealin, INCENP, and Aurora B kinase, governs essential cell division functions, including spindle… Read More
SUMMARY Traditionally, antibodies were produced using animal immunization methodologies.1 While this approach is still in broad use, recombinant display technologies have now assumed the leading role in producing antibody‐based affinity reagents. A particularly powerful aspect of these engineered reagents is that other modules having… Read More
SUMMARY SARS-CoV-2’s enters cells when the receptor binding domain (RBD) of its spike protein (S-protein) interacts with angiotensin-converting enzyme 2 (ACE2). In order to block this RBD-ACE2 interaction, clinicians need Point of Care (POC) assays to detect and neutralize the virus as early as possible. The faculty inventor has developed… Read More
SUMMARY The landscape of SARS-CoV-2 is experiencing a novel development of viral variants harboring mutations that can escape even the most highly potent antibodies against the receptor binding domain. These variants exhibit increased viral transmissibility and a partial evasion of immunity that is induced by natural infection and vaccination. Recent… Read More
SUMMARY Influenza viruses remain a global health problem, with antigenically drifting seasonal viruses and the constant risk of zoonotic influenza virus spillovers into humans. Antibodies against the major surface glycoprotein hemagglutinin (HA) are critical for providing protection against influenza virus infection. HA is divided into two domains: the globular head… Read More
SUMMARY As of February 2021, there have been over 107 million cases and over 2 million deaths caused worldwide by the novel virus SARS-CoV-2. Few vaccination and treatment approaches are currently in use with many in development. The inventors isolated antibodies specific… Read More
SUMMARY Using recombinant antibody libraries for drug development has numerous advantages over animal immunization including: faster production times, favorable expression, and not being limited by antigen immunogenicity. However, this approach is limited by the significant effort and resources required to generate such a library. The inventors developed a novel 10^10… Read More
SUMMARY Antibody fragments such as Fabs have demonstrated their utility as research tools, diagnostics, and in therapeutic applications. However, the monovalent nature of Fabs and lack of avidity is particularly limiting for binding antigens at low concentration. The inventors engineered protein G to have higher affinity and specificity for Fabs… Read More