Microbiome

Microbiome-Based Stratification and Lactulose Therapy for Infection Prevention in Advanced Liver Disease

SUMMARY Improved survival and reduced systemic infections in advanced liver disease patients by expanding gut Bifidobacteria through lactulose administration, leveraging metabolomic profiling to stratify candidates for targeted microbiome-based therapeutics The Unmet Need: High infection rates and mortality in advanced liver disease with limited targeted microbiome therapies Patients with advanced liver disease… Read More

Adaptive Microbial Platform For Gut Health, Biofuel, And Soil Productivity

SUMMARY A novel biomaterial platform designed to enhance microbial modulation, featuring tunable chemical, mechanical, and optical responsiveness for applications in health, agriculture, and industry. The Unmet Need: Current clinically deployable materials for microbiome modulation lack dynamic responsiveness, efficient biofilm enhancement, and therapeutic utility for GI disease and sustainable agriculture Soil… Read More

Oral Systemically-Bioavailable Butyrate For Treating Inflammatory Diseases

SUMMARY Method to attach butyrate to amino acids, allowing it to bypass gut metabolism and enter the bloodstream, increasing its bioavailability and enabling effective treatment of inflammatory, immune, and neurological conditions throughout the body, including the brain The Unmet Need: Methods to… Read More

Genetic Engineering Tools To Stimulate And Enhance The Production Of Select Compounds From Bacterial Species

SUMMARY Synthetic biology toolsets to genetically manipulate the microbiota, specifically non-model resident gut microbes, to alter gene expression and cellular function to produce therapeutic compounds. Unmet Need: Genetic engineering tools for gut microbes and the development of novel microbiome-based therapeutic and diagnostic systems… Read More

Microbiome-Based Therapeutic For Enhancing Anti-Tumor Immunity In Cancer Treatment

SUMMARY Innovative therapeutic strategy leveraging commensal microbiota, specifically by oral administration of Bifidobacterium, to enhance anti-tumor immunity, potentially improving cancer treatment when combined with checkpoint inhibitors   Unmet Need: Only 20-40% of patients respond to immunotherapy while a majority… Read More

Prophylactic Strategy For C. Difficile Infection Prevention

SUMMARY This technology is a prevention method for those at risk of C. difficile infection using a mutated strain of C. difficile that reduces toxicity and competes with virulent strains, offering a safer alternative to antibiotics and fecal microbiome transplants by colonizing the colon and preventing infections. Read More

Defined Live Biotherapeutic Compositions That Restore Depleted Gut Metabolites To Improve Outcomes In Liver Disease Patients

SUMMARY Patients with advanced liver disease, transplant recipients, and other critically ill populations frequently experience profound microbiome dysbiosis due to antibiotics and hospitalization. This dysbiosis is characterized by loss of microbial diversity, depletion of beneficial metabolites (e.g., butyrate, secondary bile acids), and overgrowth of pathogenic taxa, which correlates with bloodstream… Read More

Potentiating the Microbiome for the Prevention of Enteric Bacterial Infection in Livestock

SUMMARY Approximately 1/5 of antibiotic resistant infections in humans can be traced back to food and animals. The incidence of these infections is perpetuated by the widespread prophylactic use of antibiotics on farms. As such, there is an urgent need for alternative methods of preventing bacterial infection in livestock. It… Read More