SUMMARY Method to attach butyrate to amino acids, allowing it to bypass gut metabolism and enter the bloodstream, increasing its bioavailability and enabling effective treatment of inflammatory, immune, and neurological conditions throughout the body, including the brain The Unmet Need: Methods to… Read More
SUMMARY Synthetic biology toolsets to genetically manipulate the microbiota, specifically non-model resident gut microbes, to alter gene expression and cellular function to produce therapeutic compounds. Unmet Need: Genetic engineering tools for gut microbes and the development of novel microbiome-based therapeutic and diagnostic systems… Read More
SUMMARY Innovative therapeutic strategy leveraging commensal microbiota, specifically by oral administration of Bifidobacterium, to enhance anti-tumor immunity, potentially improving cancer treatment when combined with checkpoint inhibitors Unmet Need: Only 20-40% of patients respond to immunotherapy while a majority experience… Read More
SUMMARY This technology is a prevention method for those at risk of C. difficile infection using a mutated strain of C. difficile that reduces toxicity and competes with virulent strains, offering a safer alternative to antibiotics and fecal microbiome transplants by colonizing the colon and preventing infections. Read More
SUMMARY Patients with advanced liver disease, transplant recipients, and other critically ill populations frequently experience profound microbiome dysbiosis due to antibiotics and hospitalization. This dysbiosis is characterized by loss of microbial diversity, depletion of beneficial metabolites (e.g., butyrate, secondary bile acids), and overgrowth of pathogenic taxa, which correlates with bloodstream… Read More
SUMMARY Approximately 1/5 of antibiotic resistant infections in humans can be traced back to food and animals. The incidence of these infections is perpetuated by the widespread prophylactic use of antibiotics on farms. As such, there is an urgent need for alternative methods of preventing bacterial infection in livestock. It… Read More