SUMMARY Tumor Interstitial Fluid Medium (TIFM) is a pancreatic tumor-mimetic cell culture formulation, paired with matched murine PDAC cell lines adapted in either TIFM or RPMI-1640, that is designed to model nutrient conditions in the pancreatic tumor microenvironment more faithfully than standard media. The Unmet Need: Standard cell culture media… Read More
SUMMARY Automated microfluidic platform enabling high-throughput, precise 3D cell and organoid culture, drug screening, and single-cell analysis, allowing real-time monitoring and dynamic control of cellular environments for advanced research in cancer, stem cells, and personalized medicine. The Unmet Need: Platforms that can… Read More
SUMMARY Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with high efficiency and minimal off-target effects The Unmet Need: Gene editing tools that exclusively acting on cytosine… Read More
SUMMARY Trabecular (Cancellous) bone is a porous bone found in the spine and hip and is desirable for bone grafting because of its osteogenic properties. Given the difficulty of harvesting bone from the hip and spine, a method for the in vitro generation of trabecular bone is highly desired but… Read More