Therapeutics Microbiome-Based Stratification and Lactulose Therapy for Infection Prevention in Advanced Liver Disease Improved survival and reduced systemic infections in advanced liver disease patients by expanding gut Bifidobacteria through lactulose administration, leveraging metabolomic profiling to stratify candidates… Interests: Microbiome Reference ID: 23-T-112
Research Tools Therapeutics AI-Guided Genome-Wide CRISPR Platform for Novel Skin Therapeutics AI-guided CRISPR platform enables precise identification of novel therapeutic targets in primary cells, significantly enhancing drug discovery efficiency and facilitating the development of topical… Interests: Bioinformatics, Drug Development Tool, Drug Target Reference ID: 26-T-118
Diagnostics Therapeutics Senescent Epithelial Cell Targeting and Microbiota Therapy for IBD Improved inflammatory bowel disease (IBD) management by identifying and therapeutically targeting senescent colonic epithelial cells, thereby reducing mucosal inflammation through depletion of these pro-inflammatory… Interests: Biomarker, Drug Target, Gastrointestinal Reference ID: 26-T-174
Therapeutics Covalent Pan-Kinase Inhibitors and Live-Cell Activity Probes A cell-permeable, covalent multikinase activity probe that enhances selective kinase detection in native cellular environments, enabling precise profiling of kinase targets and inhibitor engagement… Interests: Cardiovascular, Dermatology, Inflammatory, Neurology, New Chemical Entity, Oncology Reference ID: 25-T-024
Therapeutics Nanoparticle Delivery of Stabilized Synthetic Transcriptional Repressors for Targeted Gene Regulation Enhanced control of disease-associated gene expression through nanoparticle delivery of stabilized DNA-binding peptides and miniproteins, improving targeted transcriptional regulation The Unmet Need: Efficient and specific… Interests: Drug Delivery Reference ID: 23-T-156
Research Tools Therapeutics Evolved riboflavin biosynthesis enzyme RibD as a novel nucleic acid deaminase for base editing. Enhanced precision in cytosine base editing by employing an evolved riboflavin biosynthesis enzyme RibD that converts targeted cytosines to thymines without intrinsic sequence-context specificity,… Interests: Gene Therapy Reference ID: 25-T-022
Therapeutics A Precision Nanomedicine Platform For Pulmonary And Organ Fibrosis A targeted nanomedicine platform for delivering therapeutics to activated fibroblasts in pulmonary fibrosis and other fibrotic diseases The Unmet Need: Current pulmonary fibrosis therapies… Interests: Pulmonary Reference ID: 20-T-082
Therapeutics Endothelium-Targeted mRNA Therapeutics For Acute And Chronic Vascular Disease Targeted delivery of therapeutic mRNA to inflamed vascular endothelial cells, achieving localized reduction of vascular inflammation and arterial plaque formation to improve treatment outcomes… Interests: Autoimmune, Cardiovascular, Inflammatory Reference ID: 22-T-182
Therapeutics Targeted mRNA Nanomedicine for ARDS and Ventilator-Induced Lung Injury A targeted nanomedicine platform improves acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) outcomes by selectively delivering therapeutic mRNA to inflamed pulmonary… Interests: Autoimmune, Inflammatory, Pulmonary Reference ID: 22-T-183
Diagnostics Therapeutics Tumor Aneuploidy Score As A Predictor Of Immunotherapy Response Tumor aneuploidy scoring delivers improved immunotherapy response prediction, enhancing personalized cancer treatment by providing prognostic insights beyond existing biomarkers like tumor mutational burden. The… Reference ID: 23-T-172
Therapeutics Novel TET2-Targeting Approaches to Induce Fetal Hemoglobin in Sickle Cell Disease and Thalassemia This technology enables increased fetal hemoglobin production to alleviate symptoms of blood disorders by modulating TET2 enzyme activity through targeted mutation and pharmacological suppression.… Reference ID: 24-T-028
Therapeutics Modular Glycopolymer Technology for Antigen-Specific Immune Tolerance This technology achieves significant reduction of anti-drug antibody responses through synthetically mannosylated antigen conjugation that induces antigen-specific humoral tolerance by enhancing hepatic immune tolerance… Reference ID: 18-T-048
