SUMMARY Targeted delivery of therapeutic mRNA to inflamed vascular endothelial cells, achieving localized reduction of vascular inflammation and arterial plaque formation to improve treatment outcomes in arterial diseases by using VCAM1-directed liposome nanoparticles. The Unmet Need: Targeted treatment of localized vascular inflammation in arterial diseases Arterial diseases such as atherosclerosis,… Read More
SUMMARY A targeted nanomedicine platform improves acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) outcomes by selectively delivering therapeutic mRNA to inflamed pulmonary microvascular endothelial cells, thereby restoring endothelial function and reducing lung damage. The Unmet Need: Effective treatments for endothelial dysfunction in ARDS and ventilator-induced lung injury… Read More
SUMMARY Method to attach butyrate to amino acids, allowing it to bypass gut metabolism and enter the bloodstream, increasing its bioavailability and enabling effective treatment of inflammatory, immune, and neurological conditions throughout the body, including the brain The Unmet Need: Methods to… Read More
SUMMARY CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance The Unmet Need: Antigen-specific therapies for tolerance induction with mitigated immune activation risk Antigen-specific immune tolerance therapies… Read More
SUMMARY Engineered recombinant fusion of the dendritic cell growth factor Flt3L to serum albumin to modulate the antigen-presenting compartment and bias it toward tolerance particularly against therapeutic proteins. The Unmet Need: Novel technologies to modulate the immune system to induce tolerance against therapeutic proteins… Read More
SUMMARY A failure of central immune tolerance typically driven by autoantigen specific T regulatory (Treg) cells is the primary cause of many autoimmune diseases. This technology generates antigen specific immune tolerance for autoimmune or transplantation therapy via induction of tolerogenic dendritic cells (tolDC, PD-L1+, CD80- CD11c+)) which facilitate the… Read More
SUMMARY Fibrosis is involved in 45% of deaths in the United States, and no treatment exists to reverse the progression of the disease. Fibrosing diseases include pulmonary fibrosis, congestive heart failure, liver cirrhosis, and end-stage kidney disease. Studies of myofibroblast differentiation have revealed the importance of properties of cell… Read More