Gastrointestinal

Senescent Epithelial Cell Targeting and Microbiota Therapy for IBD

SUMMARY Improved inflammatory bowel disease (IBD) management by identifying and therapeutically targeting senescent colonic epithelial cells, thereby reducing mucosal inflammation through depletion of these pro-inflammatory cells The Unmet Need: Insufficient therapeutic targeting of epithelial components in inflammatory bowel disease Inflammatory bowel disease, including ulcerative colitis and Crohn’s disease, is a chronic… Read More

Oral Systemically-Bioavailable Butyrate For Treating Inflammatory Diseases

SUMMARY Method to attach butyrate to amino acids, allowing it to bypass gut metabolism and enter the bloodstream, increasing its bioavailability and enabling effective treatment of inflammatory, immune, and neurological conditions throughout the body, including the brain The Unmet Need: Methods to… Read More

Genetic Engineering Tools To Stimulate And Enhance The Production Of Select Compounds From Bacterial Species

SUMMARY Synthetic biology toolsets to genetically manipulate the microbiota, specifically non-model resident gut microbes, to alter gene expression and cellular function to produce therapeutic compounds. Unmet Need: Genetic engineering tools for gut microbes and the development of novel microbiome-based therapeutic and diagnostic systems… Read More

Prophylactic Strategy For C. Difficile Infection Prevention

SUMMARY This technology is a prevention method for those at risk of C. difficile infection using a mutated strain of C. difficile that reduces toxicity and competes with virulent strains, offering a safer alternative to antibiotics and fecal microbiome transplants by colonizing the colon and preventing infections. Read More

A Surgical Stent for Impermeable Anastomoses

SUMMARY Anastomotic leak is a serious complication of gastrointestinal surgery, with consequences ranging from benign to life threatening. Treatment is costly and exposes patients to additional pain and risk. Current common anastomotic approaches include hand suturing and stapling, but there is a potential to reduce leak rates with a next-generation… Read More