SUMMARY A cell-permeable, covalent multikinase activity probe that enhances selective kinase detection in native cellular environments, enabling precise profiling of kinase targets and inhibitor engagement for improved drug development and cancer treatment strategies The Unmet Need: Selective, physiologically relevant kinase activity probes in native cellular contexts Existing kinase assays rely… Read More
SUMMARY Targeted delivery of therapeutic mRNA to inflamed vascular endothelial cells, achieving localized reduction of vascular inflammation and arterial plaque formation to improve treatment outcomes in arterial diseases by using VCAM1-directed liposome nanoparticles. The Unmet Need: Targeted treatment of localized vascular inflammation in arterial diseases Arterial diseases such as atherosclerosis,… Read More
SUMMARY A targeted nanomedicine platform improves acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) outcomes by selectively delivering therapeutic mRNA to inflamed pulmonary microvascular endothelial cells, thereby restoring endothelial function and reducing lung damage. The Unmet Need: Effective treatments for endothelial dysfunction in ARDS and ventilator-induced lung injury… Read More
SUMMARY Method to attach butyrate to amino acids, allowing it to bypass gut metabolism and enter the bloodstream, increasing its bioavailability and enabling effective treatment of inflammatory, immune, and neurological conditions throughout the body, including the brain The Unmet Need: Methods to… Read More
SUMMARY CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance The Unmet Need: Antigen-specific therapies for tolerance induction with mitigated immune activation risk Antigen-specific immune tolerance therapies… Read More
SUMMARY Engineered recombinant fusion of the dendritic cell growth factor Flt3L to serum albumin to modulate the antigen-presenting compartment and bias it toward tolerance particularly against therapeutic proteins. The Unmet Need: Novel technologies to modulate the immune system to induce tolerance against therapeutic proteins… Read More
SUMMARY Synthetic biology toolsets to genetically manipulate the microbiota, specifically non-model resident gut microbes, to alter gene expression and cellular function to produce therapeutic compounds. Unmet Need: Genetic engineering tools for gut microbes and the development of novel microbiome-based therapeutic and diagnostic systems… Read More
SUMMARY Fibrosis is involved in 45% of deaths in the United States, and no treatment exists to reverse the progression of the disease. Fibrosing diseases include pulmonary fibrosis, congestive heart failure, liver cirrhosis, and end-stage kidney disease. Studies of myofibroblast differentiation have revealed the importance of properties of cell… Read More
SUMMARY Toll-like receptor (TLR) agonists are considered promising alternatives for the estimated 50 – 75% of all cancer patients who are non-responsive to checkpoint inhibitors, and immune activation is enhanced upon stimulation of two distinct TLRs. However, the use of multiple TLR agonists as an effective therapeutic strategy is presently… Read More