SUMMARY Specially designed nanoparticles to deliver multiple cancer drugs at once, improving drug stability, targeting tumors more effectively, and reducing side effects by controlling and triggering drug release directly at the tumor site. The Unmet Need: Strategies to overcome drug degradation, off-target… Read More
SUMMARY Next-generation mRNA vaccine platform uses a lipid-polymer hybrid nanoparticle to boost stability, immune cell uptake, and T cell responses, leading to stronger and longer-lasting protection against viruses and cancer while maintaining strong antibody responses The Unmet Need: Intracellular delivery of mRNA… Read More
SUMMARY A chemical process that enables reversible, covalent RNA modification-highly selective for uridine enabling diverse functional group attachment, facilitating nucleic acid labeling The Unmet Need: Reversible labeling of native RNA in a sequence-independent and membrane-selective manner … Read More
SUMMARY A nanoscale metal-organic framework uses heavy metals to enhance X-ray absorption, triggering prodrug activation for precise cancer treatment by combining radiotherapy, chemotherapy, and immunotherapy with reduced systemic toxicity. The Unmet Need: Precise, on-demand release of chemotherapeutic and immunomodulatory agents at tumor… Read More
SUMMARY Polymersomes are a type of nanoscale vesicle made from block copolymers and can encapsulate a variety of therapeutic agents including proteins and nucleic acids. These nanovesicles are assembled at room temperature and incorporate features such as permanently charged moieties for stability and mannosylation for targeted delivery. Read More
SUMMARY A novel antibody-drug conjugate (ADC) with a lactate-responsive linker, enhancing therapeutic specificity by remaining stable in healthy tissues and releasing its therapeutic payload in high lactate tumor environments. Unmet need: A highly specific cancer drug that selectively activates in the tumor microenvironment,… Read More
SUMMARY Groundbreaking advancement in the field of mRNA topical delivery systems, providing superior penetration, stability, and biocompatibility compared to existing solutions. It opens up new possibilities for both therapeutic and cosmetic applications, paving the way for more effective and user-friendly treatments. The unmet… Read More
SUMMARY A novel drug delivery system using exosomes derived from hippocampus neuron cells engineered to express the Fe65 protein targeting amyloid-β precursor protein to reduce amyloid plaques Alzheimer's disease. This system crosses the blood-brain barrier, enhances uptake by neuronal cells, and induces autophagy, improving cognition and reduce disease pathogenesis. Read More
SUMMARY This device provides minimally invasive drug delivery and retention to the inside of the kidney The Unmet Need: This device provides minimally invasive drug delivery and retention to the inside of the kidney Administering and retaining drugs to the inside of… Read More
SUMMARY Conditioning of the immune system by the microbiome has received substantial attention for the scientific community in recent years. Microbial metabolites are being assessed as novel therapeutic tools for various diseases, including cancer and immune disorders. Butyrate is a key bacterial metabolite that plays an important and complex role… Read More
SUMMARY Adenoviruses (Ad) are a non-enveloped linear double-stranded DNA viruses with over 50 serotypes identified in humans. They have received significant attention as an in vitro and in vivo gene delivery vehicle due to their well-defined virology/biology, viral genetic stability, high gene transduction efficiency, and ability to be… Read More
SUMMARY Intracellular delivery involves introduction of small biomolecules, nucleic acids, proteins, synthetic nanomaterials and drugs into the cell. There is a lot of focus on targeted intracellular delivery for improved therapy of cancer and intracellular infections. Intracellular delivery of various drugs can sharply increase the efficiency of various treatment protocols. Read More