SUMMARY A chemical process that enables reversible, covalent RNA modification-highly selective for uridine enabling diverse functional group attachment, facilitating nucleic acid labeling The Unmet Need: Reversible labeling of native RNA in a sequence-independent and membrane-selective manner … Read More
SUMMARY Expanding CAR T cells with venetoclax enhances their ability to target and kill CD19+ tumor cells, increases their effectiveness, and reduces exhaustion, potentially leading to better treatment outcomes for diffuse large B cell lymphoma. The Unmet Need: Methods to increase CAR T efficacy… Read More
SUMMARY A class of functionally enhanced synthetic transcriptional factor antagonists to modulate the MYC/MAX transcriptional network by direct competition for DNA binding. The Unmet Need: Transcription factors remain largely untapped as pharmacologic targets due to the challenges in targeting protein–protein and protein–DNA interactions… Read More
SUMMARY Many human diseases arise from insufficient protein levels, often due to genetic mutations that result in haploinsufficiency or loss of protein function. Effectively treating these conditions necessitates therapeutic strategies capable of increasing the production of specific, vital proteins. There is a significant unmet need for programmable methods to… Read More
SUMMARY Stabilization of therapeutic proteins and peptides is often necessary to improve pharmacokinetic properties and reduce proteolysis in vivo. However, pre-existing stabilization strategies require expensive catalysts or harsh reagents that prevent preservation of certain sterically challenging protein structures. The inventors found that the Diels-Alder reaction, when performed aqueously or in… Read More