Research Tools Therapeutics Evolved riboflavin biosynthesis enzyme RibD as a novel nucleic acid deaminase for base editing. Enhanced precision in cytosine base editing by employing an evolved riboflavin biosynthesis enzyme RibD that converts targeted cytosines to thymines without intrinsic sequence-context specificity,… Interests: Gene Therapy Reference ID: 25-T-022
Therapeutics Endothelium-Targeted mRNA Therapeutics For Acute And Chronic Vascular Disease Targeted delivery of therapeutic mRNA to inflamed vascular endothelial cells, achieving localized reduction of vascular inflammation and arterial plaque formation to improve treatment outcomes… Interests: Autoimmune, Cardiovascular, Inflammatory Reference ID: 22-T-182
Therapeutics A Precision Nanomedicine Platform For Pulmonary And Organ Fibrosis A targeted nanomedicine platform for delivering therapeutics to activated fibroblasts in pulmonary fibrosis and other fibrotic diseases The Unmet Need: Current pulmonary fibrosis therapies… Interests: Pulmonary Reference ID: 20-T-082
Therapeutics Targeted mRNA Nanomedicine for ARDS and Ventilator-Induced Lung Injury A targeted nanomedicine platform improves acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) outcomes by selectively delivering therapeutic mRNA to inflamed pulmonary… Interests: Autoimmune, Inflammatory, Pulmonary Reference ID: 22-T-183
Diagnostics Software Slide-Level Uncertainty Quantification For Deep Learning Predictions In Digital Histopathology. The technology improves diagnostic accuracy in digital histopathology by providing slide-level uncertainty quantification for deep learning predictions, enabling more reliable and actionable clinical decision-making… Reference ID: 23-T-021
Diagnostics Therapeutics Tumor Aneuploidy Score As A Predictor Of Immunotherapy Response Tumor aneuploidy scoring delivers improved immunotherapy response prediction, enhancing personalized cancer treatment by providing prognostic insights beyond existing biomarkers like tumor mutational burden. The… Reference ID: 23-T-172
Diagnostics Research Tools Integration Of Semiconductor-Based Components And Functionality Into Soft Microfluidics For Cell Lysis And Other Biological Applications This technology delivers precise and scalable cellular content extraction for genomic analyses by integrating semiconductor-based piezoelectric sharp tip arrays into soft microfluidics, enabling efficient… Reference ID: 21-T-034
Research Tools Conformation-Specific HLA-F Antibodies Enable Next-Generation Immune Profiling A panel of antibody-based reagents has been developed to distinguish two conformational states of the nonclassical MHC protein HLA-F: an open conformer form and… Interests: Antibody, Biomarker, Drug Development Tool Reference ID: 22-T-062
Therapeutics Novel TET2-Targeting Approaches to Induce Fetal Hemoglobin in Sickle Cell Disease and Thalassemia This technology enables increased fetal hemoglobin production to alleviate symptoms of blood disorders by modulating TET2 enzyme activity through targeted mutation and pharmacological suppression.… Reference ID: 24-T-028
Therapeutics Modular Glycopolymer Technology for Antigen-Specific Immune Tolerance This technology achieves significant reduction of anti-drug antibody responses through synthetically mannosylated antigen conjugation that induces antigen-specific humoral tolerance by enhancing hepatic immune tolerance… Reference ID: 18-T-048
Therapeutics A Modular LOX-Mediated Delivery Platform for Solid Tumor Immunotherapy Enhanced tumor regression and immune activation through localized retention of engineered cytokines and chemokines by lysyl oxidase-mediated crosslinking to the tumor extracellular matrix improves… Reference ID: 26-T-065
Diagnostics Software Zero-burden Risk Assessment (ZeBRA) Platform for Point-in-care Universal Screening of Complex Disorders ZeBRA is a software-based platform for universal, point-of-care risk screening that uses existing EHR data to identify patients at elevated risk for complex disorders… Reference ID: 26-T-216
