SUMMARY A cell-permeable, covalent multikinase activity probe that enhances selective kinase detection in native cellular environments, enabling precise profiling of kinase targets and inhibitor engagement for improved drug development and cancer treatment strategies The Unmet Need: Selective, physiologically relevant kinase activity probes in native cellular contexts Existing kinase assays rely… Read More
SUMMARY Targeted delivery of therapeutic mRNA to inflamed vascular endothelial cells, achieving localized reduction of vascular inflammation and arterial plaque formation to improve treatment outcomes in arterial diseases by using VCAM1-directed liposome nanoparticles. The Unmet Need: Targeted treatment of localized vascular inflammation in arterial diseases Arterial diseases such as atherosclerosis,… Read More
SUMMARY A new mobile health tool for patients with obstructive sleep apnea (OSA) using a novel CPAP adherence metric and enables tracking of lifestyle features to support behavior changes to optimize care The problem: Current methods to evaluate OSA treatment fail to adequately capture CPAP adherence Obstructive sleep apnea (OSA)… Read More
SUMMARY Cardiac catherization, or angiography, is a procedure used to gain access to a patient's arterial system, and is used to treat and diagnose many heart conditions. While the transfermoral (through groin) approach has been more prevalent, the transradial (through wrist) approach (TRA) is gaining popularity due to lower complication… Read More
SUMMARY Post-CPR cardiogenic shock is associated with hemodynamic instability and poor neurological outcomes. The pathophysiology is unknown and current treatment approaches merely restore basal cardiac function and do not protect against longer term damage. The inventors demonstrated that the main mechanism leading to post-CPR cardiogenic shock is myocardial stunning, which… Read More
SUMMARY Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application is presently limited by a lack of deformability and degradability. The inventors developed a novel amorphous silicon material that retains all the advantageous properties of… Read More
SUMMARY Electric organ stimulation has shown promise in the clinic for treating aberrant neurological and cardiac activity. Problematically, this approach is limited by the high risk associated with surgical or gene editing approaches to implant these stimulation systems. The inventors engineered a specifically doped silicone wire network on a flexible… Read More
SUMMARY Abnormal myocardial oxygen usage can predict heart attack or heart transplant rejection before the onset of clinical symptoms. However, there are currently no robust and reliable methods for globally measuring myocardial oxygen use and tissue strain despite the capability of this diagnostic tool to offer patients earlier access to… Read More
SUMMARY A trace amount of electrically conductive silicon nanowires (e-SiNWs) into otherwise scaffold-free hiPSC-derived cardiomyocyte spheroids to improve electrical coupling, synchronized beating, calcium handling, and structural maturation. The Unmet Need: Human iPSC-derived cardiomyocytes are widely used but remain functionally immature, limiting their predictive value in drug screening and their usefulness… Read More