SUMMARY A cell-permeable, covalent multikinase activity probe that enhances selective kinase detection in native cellular environments, enabling precise profiling of kinase targets and inhibitor engagement for improved drug development and cancer treatment strategies The Unmet Need: Selective, physiologically relevant kinase activity probes in native cellular contexts Existing kinase assays rely… Read More
SUMMARY Methods to improve radiotherapy by blocking the protein Amphiregulin (AREG), which helps tumors resist treatment and spread. Inhibiting AREG enhances anti-tumor effects and reduces metastasis, making radiotherapy more effective The Unmet Need: Methods to mitigate the underlying biological mechanisms that… Read More
SUMMARY A method using tumor sequencing data to measure membrane-localized neoantigens, helping predict which cancer patients will benefit from immunotherapy, even those with low tumor mutational burden, improving treatment selection and survival outcomes The Unmet Need: Improved biomarkers that more accurately… Read More
SUMMARY A vaccine platform that uses engineered lymphangiogenesis factors and antigens to stimulate lymphatic endothelial cells, creating strong, long-lasting immune memory or tolerance with fewer side effects than traditional vaccines The Unmet Need: Targeted and durable immune modulation while minimizing systemic toxicity… Read More
SUMMARY Engineered T cells to release cancer-killing proteins only when activated by targeted radiation, enabling precise, localized tumor treatment while minimizing side effects and improving the effectiveness of CAR-T therapy for solid tumors The Unmet Need: Precise spatial and temporal delivery of… Read More
SUMMARY Next-generation mRNA vaccine platform uses a lipid-polymer hybrid nanoparticle to boost stability, immune cell uptake, and T cell responses, leading to stronger and longer-lasting protection against viruses and cancer while maintaining strong antibody responses The Unmet Need: Intracellular delivery of mRNA… Read More
SUMMARY A matched pair of photoproximity probes coupled with quantitative proteomics which enable context-dependent mapping of protein complex topology inside cells including to map MYC interactomes across temporal, spatial and disease-relevant contexts The Unmet Need: The ability to map… Read More
SUMMARY Enhanced anti-tumor immunity through immunomodulation is achieved by fatty acids that activate CD8+ T cells, thereby improving cancer immunotherapy efficacy and reducing T-cell exhaustion. The Unmet Need: Limited effectiveness of current cancer immunotherapies due to T-cell dysfunction and exhaustion Current cancer immunotherapies, including immune checkpoint inhibitors and CAR… Read More
SUMMARY A novel mechanism for 5-azacytidine-mediated depletion of RNA 5-methylcytosine on chromatin-associated RNA leading to global transcriptional repression through two epigenetic pathways enabling more precise and effective leukemia treatments The Unmet Need: Optimized 5-azacytidine therapeutic strategies and reliable biomarkers… Read More
SUMMARY Novel antibodies to rapidly and safely expand γδ T cells enabling large-scale production for cancer immunotherapies like γδ CAR-T cells, and potentially boosting these cells directly in patients The Unmet Need: Efficient large-scale expansion of γδ T cells with enhanced… Read More
SUMMARY Novel antibodies precisely targeting cancer cells by binding to the Prolactin Receptor (PRLR) to diagnose cancer, direct immune cells to destroy tumors, and inhibit cancer growth signals, without affecting healthy cells The Unmet Need: Novel antibodies to effectively modulate cancer cell… Read More
SUMMARY Method to enhance CAR T-cell efficacy by incorporating low-dose exogenous IFN-α2 into CD19-directed, CD28-costimulated CAR T cells post-transduction during manufacturing boosting cytolytic molecule expression, cytokine secretion, and cytotoxicity while minimizing apoptosis The Unmet Need: Enhanced CAR T-cell effector function through modulation… Read More