SUMMARY A matched pair of photoproximity probes coupled with quantitative proteomics which enable context-dependent mapping of protein complex topology inside cells including to map MYC interactomes across temporal, spatial and disease-relevant contexts The Unmet Need: The ability to map the… Read More
SUMMARY Phosphorodiamidate morpholino oligomer (PMO)-based RNA-degrading chimeras reduce α-synuclein protein by degrading its messenger RNA preventing protein aggregation and propagation associated with neurodegenerative diseases. The Unmet Need: More potent and selective therapeutic strategies for neurodegenerative α-synucleinopathies Neurodegenerative diseases such as… Read More
SUMMARY Novel antibodies to rapidly and safely expand γδ T cells enabling large-scale production for cancer immunotherapies like γδ CAR-T cells, and potentially boosting these cells directly in patients The Unmet Need: Efficient large-scale expansion of γδ T cells with enhanced… Read More
SUMMARY Quantum nanoprobe system enables real-time probing of intracellular chemical environments and activity to advance biological and medical diagnostics The Unmet Need: Novel ways to probe cellular processes and improve biological sensing Understanding complex cellular processes in real-time at the single-cell level… Read More
SUMMARY Genetically encoded synthetic antibody fragments, expressed intracellularly, to specifically bind the mTOR FKBP12-Rapamycin binding domain inhibiting mTORC1 and mTORC2 activity. Fused with localization signals, these tools enable precise, compartment-specific modulation of mTOR signaling for research and therapeutic exploration The Unmet Need:… Read More
SUMMARY Novel proximity labeling technology utilizes a bioorthogonal protecting group, impervious to endogenous esterases, paired with evolved BS2 esterase mutants. The enzyme-mediated unmasking creates a reactive acid chloride intermediate that rapidly labels adjacent RNA, ensuring high specificity and sensitivity for biomolecule mapping within living cells. Read More
SUMMARY CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance The Unmet Need: Antigen-specific therapies for tolerance induction with mitigated immune activation risk Antigen-specific immune tolerance therapies… Read More
SUMMARY Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with high efficiency and minimal off-target effects The Unmet Need: Gene editing tools that exclusively acting on cytosine… Read More
SUMMARY A breakthrough method to systematically select for optimal small guide RNAs using an unbiased approach for improved accuracy and efficiency of all systems of site-directed RNA editing. The Unmet Need: In vitro assays that reliably predict guide RNA efficiency and specificity before in… Read More
SUMMARY Novel machine learning-enable platform to guide in vitro experimental screening and discovery of small molecule immunomodulators to improve immune responses The unmet need: Platform to resolve unregulated immune potentiator enhancement and suppression of inflammatory and stimulatory responses The innate immune response… Read More
SUMMARY DNA hypomethylating agents have been widely used to treat various hematologic and non-hematologic malignancies. However, accumulating evidence has demonstrated that DNA methylation status does not correlate with clinical response to hypomethylating agents. Two RNA cytosine methyltransferases (RCMTs) NSUN1 and NSUN2 are responsible for catalyzing the majority of 5-methylcytosine in… Read More
SUMMARY Traditionally, antibodies were produced using animal immunization methodologies.1 While this approach is still in broad use, recombinant display technologies have now assumed the leading role in producing antibody‐based affinity reagents. A particularly powerful aspect of these engineered reagents is that other modules having… Read More