SUMMARY The engineered hypercompact enAsCas12f system addresses CRISPR-Cas systems deliverability issues while offering enhanced gene-editing high specificity making it ideal for therapeutic applications using AAV delivery. The unmet Need: New CRISPR-systems with greater deliverability and higher gene editing capabilities CRISPR-Cas (clustered regularly interspaced short… Read More
SUMMARY A chemical process that enables reversible, covalent RNA modification-highly selective for uridine enabling diverse functional group attachment, facilitating nucleic acid labeling The Unmet Need: Reversible labeling of native RNA in a sequence-independent and membrane-selective manner The study… Read More
SUMMARY N-Acetylcysteine (NAC) is commonly used to break down mucous and lessen lung function decline but has traditionally shown low efficacy in treating patients with idiopathic pulmonary fibrosis (IPF). The only two FDA approved drugs to treat IPF have severe side effects, meaning there is an urgent need to find… Read More