Medical

Adaptive Microbial Platform For Gut Health, Biofuel, And Soil Productivity

SUMMARY A novel biomaterial platform designed to enhance microbial modulation, featuring tunable chemical, mechanical, and optical responsiveness for applications in health, agriculture, and industry. The Unmet Need: Current clinically deployable materials for microbiome modulation lack dynamic responsiveness, efficient biofilm enhancement, and therapeutic utility for GI disease and sustainable agriculture Soil… Read More

New Reversible Uridine Modification Chemistry For Labeling and Functionalizing Native Nucleic Acids

SUMMARY A chemical process that enables reversible, covalent RNA modification-highly selective for uridine enabling diverse functional group attachment, facilitating nucleic acid labeling The Unmet Need: Reversible labeling of native RNA in a sequence-independent and membrane-selective manner  … Read More

Scalable Bioelectronic Production Of Extracellular Vesicles For Regenerative Medicine

SUMMARY Bioelectronic devices and methods for the electrical stimulation of cells and engineered tissue for the scalable production of extracellular vesicles for drug delivery and regenerative medicine. The Unmet Need: New techniques for mass production of extracellular vesicles Extracellular vesicles (EVs) are important membrane-enclosed… Read More

Bioadhesive Polymer for Connecting Semiconductors to Wet Tissue

SUMMARY This method imparts bioadhesive properties onto polymeric semiconductors, which enables effective transductions of bio-signals from biological tissues to electronic devices. The Unmet Need: Conformable and stable integration… Read More

New Class of Biocompatible and Flexible Optoelectronic Devices For Next Generation Pacemakers

SUMMARY Electrode-based electrical stimulation underpins several clinical bioelectronic devices, including deep brain stimulators and cardiac pacemakers. Pacemaker therapy improves quality of life and reduces mortality rates. Despite significant advances, current pacemaker therapies are fraught with risks. With conventional endocardial pacing, complications mainly arise from the transvenous lead or subcutaneous generator… Read More

A New Method of Isotope Enrichment and Separation: Preferential Embedding of Heavier Isotopes Into Ices

SUMMARY Isotope separation methods are key to numerous scientific and industrial processes. Nuclear power plants and weapons, for example, require fuels enriched in a select isotope. And isotopically pure or enriched samples are used in scientific research and medical procedures. Isotopes can be separated via fractional distillation, gaseous diffusion, and… Read More

New System for the Synthesis of Silicon-Based Materials for Biological Modulation

SUMMARY Pure silicon materials with strong photoelectrochemical properties are  advantageous to biomodulations devices due to their excellent dielectric properties that are promising in many electrical transmission applications. Synthesis of such materials have previously been completed with dopant modulation but lack efficiency and fast production. This technology addresses prior shortcomings by… Read More

Targeted Nanotherapeutic Nucleotide Delivery For Preventing Arteriovenous Fistula Failure

SUMMARY Surgically created arteriovenous fistula (AVF) is the preferred vascular access means for treating terminal renal failure through hemodialysis. 60% of AVF’s fail as effective dialysis points due to vascular stenosis. This disturbed blood flow stimulates vascular inflammation by increasing the expression of vascular cell adhesion… Read More

Monolithic (Binder Free) Carbon-Based Bioelectronic Devices for Biomodulation and Electroceutical Applications

SUMMARY The global electroceuticals market is expected to reach $25+ billion by 2021.  Modern biolectronics with multi-scale structures are used extensively for drug delivery, biosensing, and biological modulations.  However, macroscopic bioelectronic devices are usually rigid and mechanically invasive to cells and tissues.  Therefore, nanostructuring of the bioelectronics surfaces represents a… Read More