Therapeutics Peripherally Restricted Κ-Opioid Receptor Agonist Co-Formulation For Preventing Opioid-Induced Respiratory Depression An opioid painkiller combined with a peripherally restricted κ-opioid receptor agonist stimulating the carotid body to prevent opioid-induced respiratory depression, enhancing breathing without affecting… Interests: Small Molecules Reference ID: 25-T-071 Desired Partnership: Co-development, Licensing IP: Patent Pending
Medical Devices A Wearable Bioelectronic Patch For Controlling Bacterial Pathogens Without Antibiotics A wearable patch using an acidic hydrogel and low-voltage electricity to safely reduce harmful bacteria on skin. The bioelectric system sensitizes bacteria, then modulates… Reference ID: 25-T-029 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for… Interests: Biologics, Gene Therapy, Infectious Disease, Tangible Property Reference ID: 25-T-198 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Bioorthogonal Enzyme-Probe System For Spatially Specific Biomolecule Labeling Novel proximity labeling technology utilizes a bioorthogonal protecting group, impervious to endogenous esterases, paired with evolved BS2 esterase mutants. The enzyme-mediated unmasking creates a… Interests: Drug Development Tool Reference ID: 25-T-114 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Site-Directed RNA Editing Technology As A Novel Analgesic Use of RNA editing to modify NaV1.7 sodium channels in nociceptors, making them permeable to Na+ and K+ ions reducing the excitability of these… Reference ID: 23-T-068 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Ketone Carbonyl Atom Swap Platform For Drug Discovery And Lead Optimization A two-step chemical process using a special reagent to swap a ketone's oxygen atom with a sulfur atom creating new compounds, particularly useful for… Interests: Chemical Synthesis, Chemical Synthesis Reference ID: 25-T-072 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Context-Specific Cytosine Base Editors For Precise Single-Nucleotide DNA Editing Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with… Interests: Cell Line, Drug Development Tool, Gene Therapy Reference ID: 24-T-089 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics CD200-Antigen Fusion Proteins For Myeloid-Targeted Antigen-Specific Immune Tolerance CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance… Interests: Allergy, Autoimmune, Drug Development Tool, Inflammatory Reference ID: 24-T-085 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Gene Splice-Switching Technology for Treating CACNA1A-Associated Neurological Diseases This technology regulates the expression of the CACNA1A gene, which encodes a neuronal calcium channel subunit, by redirecting alternative splicing to treat related neurological… Interests: Musculoskeletal, Neurology, Rare/Orphan Diseases Reference ID: 24-T-060 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Engineered Mutator tRNAs For Correcting Missense Genetic Defects And Inducing Cancer Cell Death Engineered tRNAs with altered anticodons and chemical modifications deliver the correct amino acid at mutated codons to restore protein function in genetic diseases or… Interests: Biologics, Oncology Reference ID: 22-T-111 Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Low-Input Methylation Sequencing For Profiling Epitranscriptomic Signatures And Early Colorectal Cancer Diagnosis A method that analyzes cfRNA methylation in plasma to distinguish human RNA from microbiome RNA, accurately detecting colorectal cancer through specific methylation markers even… Interests: Epigenetics, Microbiology/Virology, Sequencing Reference ID: 24-T-187 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Antibody-Based Therapeutics For Inhibiting Growth Hormone Receptor Dimerization And Signaling Antibodies that block growth hormone signaling by binding the receptor or hormone to stop receptor pairing, based on high-affinity, defined sequences for therapeutic and… Interests: Antibody, Rare/Orphan Diseases Reference ID: 23-T-100 Desired Partnership: Co-development, Licensing IP: Patent Pending
