SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide. In the United States, there are 1.1 million burn injuries which require medical attention each year. These injuries often result in significant scarring having a negative impact on the… Read More
SUMMARY The field of oncological diagnostics and therapeutics has long sought methods to refine treatment approaches for aggressive cancers. In conditions such as advanced high-grade ovarian cancer, there is a critical need for techniques that can accurately predict therapeutic responses and guide personalized treatment decisions. This is driven by the… Read More
SUMMARY Innovative therapeutic strategy leveraging commensal microbiota, specifically by oral administration of Bifidobacterium, to enhance anti-tumor immunity, potentially improving cancer treatment when combined with checkpoint inhibitors Unmet Need: Only 20-40% of patients respond to immunotherapy while a majority experience… Read More
SUMMARY Radiotherapy and immunotherapy are used to treat many cancer types, yet only 50% and 20% of patients respond, respectively. Resistance to therapy presents a large problem. N6-methyladenosine (m6A) modification is commonly found in on RNA in eukaryotic cells. By binding to m6A sites, YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein… Read More
SUMMARY An estimated 20-30% of breast cancer patients suffer from metastatic recurrence, which can be perpetuated by an overreliance on high doses of a single drug during initial treatment. In addition to promoting recurrence, ths treatment approach can also reduce drug sensitivity during relapse. The Raf kinase inhibitor protein, RKIP,… Read More