SUMMARY A method using tumor sequencing data to measure membrane-localized neoantigens, helping predict which cancer patients will benefit from immunotherapy, even those with low tumor mutational burden, improving treatment selection and survival outcomes The Unmet Need: Improved biomarkers that more accurately… Read More
SUMMARY A vaccine platform that uses engineered lymphangiogenesis factors and antigens to stimulate lymphatic endothelial cells, creating strong, long-lasting immune memory or tolerance with fewer side effects than traditional vaccines The Unmet Need: Targeted and durable immune modulation while minimizing systemic toxicity… Read More
SUMMARY Next-generation mRNA vaccine platform uses a lipid-polymer hybrid nanoparticle to boost stability, immune cell uptake, and T cell responses, leading to stronger and longer-lasting protection against viruses and cancer while maintaining strong antibody responses The Unmet Need: Intracellular delivery of mRNA… Read More
SUMMARY Method to enhance CAR T-cell efficacy by incorporating low-dose exogenous IFN-α2 into CD19-directed, CD28-costimulated CAR T cells post-transduction during manufacturing boosting cytolytic molecule expression, cytokine secretion, and cytotoxicity while minimizing apoptosis The Unmet Need: Enhanced CAR T-cell effector function through modulation… Read More
SUMMARY A panel of pan-specific Vγ9Vδ2 TCR-recognizing antibodies that allosterically trigger T-cell activation to engage and kill cancer cells, making it highly applicable for targeted cancer therapy. The Unmet Need: Strategy to safely and effectively harness Vγ9Vδ2 T cells for immunotherapeutic interventions… Read More
SUMMARY Nutraceutical approach using specific fatty acids naturally found in human breast milk incorporated into infant formula enhancing immune defense in both neonates and adults The Unmet Need: Solutions for effectively bridging maternal and infant health and immune development through diet The field… Read More
SUMMARY The field of oncological diagnostics and therapeutics has long sought methods to refine treatment approaches for aggressive cancers. In conditions such as advanced high-grade ovarian cancer, there is a critical need for techniques that can accurately predict therapeutic responses and guide personalized treatment decisions. This is driven by the… Read More
SUMMARY A novel chimeric antigen coreceptor system mimicking the CD4/CD8 and TCR interaction to enhance signaling for increased antigen sensitivity to treat B cell malignancies. The unmet need: Solutions for CAR therapy insufficient efficacy and clinical non-response/relapse CAR-T cells are T cells… Read More
SUMMARY Innovative therapeutic strategy leveraging commensal microbiota, specifically by oral administration of Bifidobacterium, to enhance anti-tumor immunity, potentially improving cancer treatment when combined with checkpoint inhibitors Unmet Need: Only 20-40% of patients respond to immunotherapy while a majority experience… Read More
SUMMARY New cancer therapy to enhance the efficacy of checkpoint inhibitor immunotherapy and radiation by blocking tumor-promoting signals from erythroid progenitor cells, which secrete artemin to advance cancer progression. This approach targets artemin and its signaling axis to improve treatment outcomes. The problem: Tumor cells exploit numerous signaling… Read More
SUMMARY Novel machine learning-enable platform to guide in vitro experimental screening and discovery of small molecule immunomodulators to improve immune responses The unmet need: Platform to resolve unregulated immune potentiator enhancement and suppression of inflammatory and stimulatory responses The innate immune response… Read More
SUMMARY A major attention of vaccine adjuvant development has been focused on development of robust antibody-mediated protection against pathogens. However, such adjuvants have failed to elicit a robust T-cell mediated protection and are thus found to be less efficacious against diseases like malaria, tuberculosis, Ebola and Zika or in immunotherapy. Read More