Research Tools Therapeutics Activity-responsive Split RNA Polymerase Platform for Biosensors and Gene Therapy An understanding of protein-protein interactions (PPIs) is critical to uncovering new disease pathophysiology and for developing small molecule and antibody treatments. Problematically, current approaches… Interests: Biologics, Drug Delivery, Drug Screening, Gene Therapy Reference ID: 16-T-069 Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Therapeutics Genetic Signature to Predict NAC Efficacy in Treating Idiopathic Pulmonary Fibrosis (IPF) N-Acetylcysteine (NAC) is commonly used to break down mucous and lessen lung function decline but has traditionally shown low efficacy in treating patients with… Interests: Genomics Reference ID: 15-T-034 Desired Partnership: Co-development, Licensing IP: Patent Pending
Medical Devices Therapeutics A Combined Therapy and Imaging Beam Dose Algorithm for Optimal Image-guided Radiation Therapy kV radiation dose for imaging tumors is useful for direct monitoring and real-time organ tracking without relying on high-risk surgical implants. However, the utility… Interests: Drug Screening, Imaging, Oncology Radiotherapy, Oncology Solid Tumor Reference ID: 14-T-016 Desired Partnership: Licensing IP: Patent Issued
Therapeutics Synergistic Combination of Immunologic Inhibitors for the Treatment of Cancer Current immunotherapy approaches often focus on targeting a single immune checkpoint or suppressive pathway, which can be insufficient given the redundancy and adaptability of… Interests: Antibody, Biologics, Immunotherapy, Oncology, Oncology Hematopoietic, Oncology Solid Tumor Reference ID: 12-T-132 Desired Partnership: Licensing IP: Patent Issued
Therapeutics siRNA/shRNA Therapy for the Sensitization of Treatment-resistant Solid Tumors to Chemo and Radiation Therapy Adjuvant radiation therapy post-surgery remains largely ineffective, with just 5% of patients showing a survival benefit. Small molecule JAK inhibitors have shown efficacy in… Interests: Oncology, Oncology Hematopoietic, Oncology Radiotherapy, Oncology Solid Tumor Reference ID: 12-T-099 Desired Partnership: Co-development, Licensing IP: Patent Issued
Therapeutics Novel Small Molecule Treatment for Staphylococcus Aureus SSTI Infections SUMMARY Staphylococcus aureus infects 50,000 patients and kills 20,000 annually in the United States alone. With widespread antibiotic resistance, there is an urgent need… Interests: Antibody, Biologics, Drug Screening, Infectious Disease Reference ID: 10-T-108 Desired Partnership: Co-development, Licensing IP: Patent Issued
Diagnostics Therapeutics IRDS: Predictive 7-gene Signature for Breast Cancer Therapy After surgical removal of breast cancer tumors, adjuvant chemotherapy and radiation therapy have an absolute survival benefit of just 5-10%. Currently approved breast cancer… Reference ID: 05-T-101 Desired Partnership: Licensing IP: Patent Issued
Therapeutics A Potent Glioma Targeting CAR T-Cell With Minimal Off-Target Toxicity IL13Ra2 is a cancer testis antigen that is expressed in 50-80% of glioblastoma cells, has no basal expression in the healthy tissue, and is… Interests: Biologics, Oncology Solid Tumor Reference ID: 15-T-006 Desired Partnership: Licensing IP: Patent Issued
Therapeutics A Low Dose, Multi-drug Cocktail for the Treatment of Metastatic and Resistant Breast Cancers An estimated 20-30% of breast cancer patients suffer from metastatic recurrence, which can be perpetuated by an overreliance on high doses of a single… Interests: Combination Therapy, Oncology, Oncology Solid Tumor Reference ID: 18-T-043 Desired Partnership: Co-development, Licensing IP: Patent Pending
Other Method for the in Vitro Generation of Trabecular Bone Trabecular (Cancellous) bone is a porous bone found in the spine and hip and is desirable for bone grafting because of its osteogenic properties.… Interests: Biologics, Cell Line, Drug Screening, Musculoskeletal Reference ID: 15-T-107 Desired Partnership: Co-development, Licensing IP: Patent Pending
Software Human Brain-Inspired Algorithm for Neural Network “Memory” Catastrophic forgetting or interference is the inability of an artificial neural network (ANN) to learn multiple sequential tasks without a degradation in the accuracy… Interests: Machine Learning/Artificial Intelligence Reference ID: 18-T-086 Desired Partnership: Co-development, Investment, Licensing IP: Patent Issued
Diagnostics Therapeutics Neurophysiological Biomarker for Early ALS Detection Presently, physicians rely on a costly and invasive battery of tests for diagnosing ALS. Early detection of ALS can improve patient survival and quality… Interests: Healthcare IT, Neurology Reference ID: 18-T-074 Desired Partnership: Co-development, Investment, Licensing IP: Patent Pending
