SUMMARY This technology regulates the expression of the CACNA1A gene, which encodes a neuronal calcium channel subunit, by redirecting alternative splicing to treat related neurological diseases. This approach can potentially correct gene expression variations linked to disorders including episodic ataxia, migraines, epilepsy,… Read More
SUMMARY Frailty is a condition that often affects the elderly. It is characterized by increased susceptibility to physiologic stressors such as illness and major surgery. Screening for frailty in our thoracic surgery population indicates that nearly 70% of patients are frail or prefrail at the time they are referred to… Read More
SUMMARY Spinocerebellar ataxia type 6 (SCA6) is a rare, dominantly inherited disease that causes Purkinje cell degradation and results in: loss of coordination, tremors, and uncoordinated muscle movement. Current therapies only mitigate symptoms and do not address the underlying pathophysiology responsible for disease progression. It is known that individuals with… Read More
SUMMARY Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application is presently limited by a lack of deformability and degradability. The inventors developed a novel amorphous silicon material that retains all the advantageous properties of… Read More
SUMMARY Calcium phosphates have chemical similarity to bones and teeth, and as such, these compounds are highly desired for orthopedic and dental implant applications. However, current formulations have limited bioavailability and compressive strength, which limits the clinical utility of these materials. The inventors developed a method to synthesize polymer stabilized… Read More
SUMMARY Trabecular (Cancellous) bone is a porous bone found in the spine and hip and is desirable for bone grafting because of its osteogenic properties. Given the difficulty of harvesting bone from the hip and spine, a method for the in vitro generation of trabecular bone is highly desired but… Read More