SUMMARY Engineered T cells to release cancer-killing proteins only when activated by targeted radiation, enabling precise, localized tumor treatment while minimizing side effects and improving the effectiveness of CAR-T therapy for solid tumors The Unmet Need: Precise spatial and temporal delivery of… Read More
SUMMARY A nanoscale metal-organic framework uses heavy metals to enhance X-ray absorption, triggering prodrug activation for precise cancer treatment by combining radiotherapy, chemotherapy, and immunotherapy with reduced systemic toxicity. The Unmet Need: Precise, on-demand release of chemotherapeutic and immunomodulatory agents at tumor… Read More
SUMMARY New cancer therapy to enhance the efficacy of checkpoint inhibitor immunotherapy and radiation by blocking tumor-promoting signals from erythroid progenitor cells, which secrete artemin to advance cancer progression. This approach targets artemin and its signaling axis to improve treatment outcomes. The problem: Tumor cells exploit numerous signaling… Read More
SUMMARY Advanced imaging and targeted radiotherapy for neuroendocrine tumors, using DOTATATE-based agents for precise diagnosis and treatment, and enhancing therapy effectiveness by adding Fulvestrant as a radiosensitizer to further reduce tumor growth The Unmet Need: More effective neuroendocrine tumor treatments that… Read More
SUMMARY Radiotherapy and immunotherapy are used to treat many cancer types, yet only 50% and 20% of patients respond, respectively. Resistance to therapy presents a large problem. N6-methyladenosine (m6A) modification is commonly found in on RNA in eukaryotic cells. By binding to m6A sites, YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein… Read More
SUMMARY Stereotactic ablative body radiotherapy (SART) is the precise delivery of concentrated radiation beams to a tumor from different angles. Due to the cross interaction between beams, SART is rarely able to be applied in the simultaneous treatment of multiple metastatic lesions, despite the potential benefit to patients who have… Read More
SUMMARY Vaccine efficacy is limited due to the inability to deliver in-tact antigens to antigen presenting (APC) dendritic cells (DCs) while simultaneously activating the cells in a non-toxic fashion. Adjuvants have been used in an attempt to overcome the issues of vaccine efficacy, however they are poorly soluble which results… Read More
SUMMARY Adjuvant radiation therapy post-surgery remains largely ineffective, with just 5% of patients showing a survival benefit. Small molecule JAK inhibitors have shown efficacy in the clinic at treating these patients, yet problematically this approach is plagued by off-target toxicities and eventual development of treatment resistance. The inventors used an… Read More
SUMMARY kV radiation dose for imaging tumors is useful for direct monitoring and real-time organ tracking without relying on high-risk surgical implants. However, the utility of this approach is limited by concerns of radiation overdose associated with exposing patients to an additional radiation source other than the MV treatment dose. Read More
SUMMARY Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation, the regulation of the enzymes that control it is poorly understood. The inventors designed an enzyme substrate analogue probe… Read More
SUMMARY A cell-active RAD51 inhibitor scaffold with an optimized reversible analog that reduces reactivity liabilities and is well suited for research-use commercialization and further oncology lead optimization The Unmet Need: Selective, biologically stable tools to inhibit RAD51-mediated homologous recombination to study DNA repair biology and overcome resistance to DNA-damaging therapies… Read More