SUMMARY University of Chicago researchers have developed a method to enable higher-resolution imaging beyond pixelated detector limits by moving absorption or sensor-sensitivity patterns across a signal and computationally reconstructing images beyond a pixelated detector’s intrinsic resolution. This technology could improve cellular-scale tracer mapping… Read More
SUMMARY A method uses AI and clustering to remove lesions from breast MRI images, reconstructing clearer projection images for more accurate assessment of tissue enhancement and improved breast cancer risk evaluation. The Unmet Need: Automated techniques to accurately distinguish and isolate lesions… Read More
SUMMARY A light-sensitive version of LifeAct, a peptide used to label actin in cells, to reduce its harmful side effects by controlling its binding through light exposure, improving cell imaging and minimizing cytoskeletal disruptions The Unmet Need: Innovative solutions that can provide… Read More
SUMMARY Despite the many advances in the field of resuscitation post cardiac arrest, hypoxic-ischemic brain injury (HIBI) leaves many survivors with severe neurological disability. Patients who remain comatose at 24–72 h or more after resuscitation undergo neuroprognostication, aimed to detect signs… Read More
SUMMARY An advanced Positron Emission Tomography (PET) detector system that achieves lower radiation dose and higher spatial and temporal resolution by utilizing ionization-activated organic fluor molecules combined with time-of-flight and optical imaging, thereby enhancing diagnostic accuracy and patient safety in medical imaging. The Unmet Need: Need for improved PET imaging with… Read More
SUMMARY Residual bubble clouds decrease the therapeutic efficacy of ablative ultrasound therapy. Ultrasound pulses can be used to destroy residual bubbles, however constructive interference limits simultaneous imaging and monitoring. The inventors developed a method to use plane wave B-mode imaging for the simultaneous generation of bubble deleting pulses and real… Read More
SUMMARY Pedicled left internal mammary artery (LIMA) bypass grafts are performed in over 90% of coronary artery bypass graft surgeries. The grafted vasculature potentially requires future angiographic surveillance or catheterization, with the right transradial approach being the safest and most ergonomically favored vascular access approach. Despite this, there is currently… Read More
SUMMARY Optical imaging techniques are limited by diffraction or acquisition time, making imaging through solid materials at the molecular level particularly challenging. As such, current spectroscopy approaches are significantly limited in the resolution of the images captured. The inventors developed a novel optical resonance imaging technique that uses two laser… Read More
SUMMARY Current UV-Vis protocols require long acquisition times which prevents the acquisition of data on electron dynamics. This in turn limits the resolution with which UV-Vis can be used for certain applications such as contaminant identification. The inventors developed a technology called Gradient-Assisted Photon Echo Spectroscopy (GRAPE), which acquires the… Read More
SUMMARY Abnormal myocardial oxygen usage can predict heart attack or heart transplant rejection before the onset of clinical symptoms. However, there are currently no robust and reliable methods for globally measuring myocardial oxygen use and tissue strain despite the capability of this diagnostic tool to offer patients earlier access to… Read More
SUMMARY Presently, the use of single cell methods such as RNA sequencing can identify rare inflammatory cellular populations that can be used for the diagnosis of autoimmune disorders. However, the scope of current technologies is limited in that they do not convey information on the architecture of the cellular inflammation… Read More
SUMMARY kV radiation dose for imaging tumors is useful for direct monitoring and real-time organ tracking without relying on high-risk surgical implants. However, the utility of this approach is limited by concerns of radiation overdose associated with exposing patients to an additional radiation source other than the MV treatment dose. Read More