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Residual Bubble Control to Boost Ablative Ultrasound Efficacy

Published:
Lead Inventor: Kenneth Bader
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SUMMARY

  • Residual bubble clouds decrease the therapeutic efficacy of ablative ultrasound therapy. Ultrasound pulses can be used to destroy residual bubbles, however constructive interference limits simultaneous imaging and monitoring.
  • The inventors developed a method to use plane wave B-mode imaging for the simultaneous generation of bubble deleting pulses and real time imaging of residual bubble clouds.
  • The product is a software package for the simultaneous real-time monitoring and deletion of residual bubbles during ablative ultrasound procedures. The software is compatible with a wide range of thermal and mechanical therapeutic ultrasound machines.
  • The inventors used a phantom mimicking human tissue to demonstrate the capability of their system to reduce bubble decay time by 47-67% as measured by bubble gray scale-size. The decay rate varied with bubble deleting pulse duration.

FIGURE

Plot showing a significant reduction in bubble dissolution time when the peak negative pressure of the plane wave imaging pulse was increased from 0.5 t0 6.7 MPa. Bar color denotes pulse length.

ADVANTAGES

ADVANTAGES

  • Real time residual bubble imaging
  • Residual bubble control during procedure (no stopping required)
  • Improved treatment efficacy and patient outcomes

APPLICATIONS

  • Ablative ultrasound therapy

 

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