SUMMARY Inventors devised a nanomedicine termed “Nanotraps” that can completely capture and eliminate SARS-CoV-2 by triggering macrophages to engulf and clear the virus without becoming infected. Ex vivo lung perfusion system. Zero toxicity was found in mice as evidenced by histological analysis of heart, liver, spleen, lung, and kidney, as… Read More
SUMMARY The global electroceuticals market is expected to reach $25+ billion by 2021. Modern biolectronics with multi-scale structures are used extensively for drug delivery, biosensing, and biological modulations. However, macroscopic bioelectronic devices are usually rigid and mechanically invasive to cells and tissues. Therefore, nanostructuring of the bioelectronics surfaces represents a… Read More
SUMMARY Residual bubble clouds decrease the therapeutic efficacy of ablative ultrasound therapy. Ultrasound pulses can be used to destroy residual bubbles, however constructive interference limits simultaneous imaging and monitoring. The inventors developed a method to use plane wave B-mode imaging for the simultaneous generation of bubble deleting pulses and real… Read More
SUMMARY Embryonic and fetal hemoglobin have a higher affinity for oxygen than their adult counterpart, and as such, gene editing techniques to revert red blood cells to produce infant or fetal hemoglobin are being explored for the treatment of sickle cell anemia. Problematically, these techniques require the use of toxic… Read More
SUMMARY Currently there is no available vaccine for the prophylaxis of S. Aureus mediated infections such as MRSA, and antibiotics such as beta lactams and oxacillin are most commonly used for treatment. However, widespread and repeated use of these antibiotics is promoting treatment resistant infection. The autoregulated VraSR operon is… Read More
SUMMARY Optimized small-molecule inhibitors of RAD51 that selectively suppress D-loop formation and homologous recombination The Unmet Need: Selective agents that suppress homologous recombination repair without off-target toxicity. RAD51 is a central protein in homologous recombination, a DNA repair pathway that helps cells repair double-strand breaks accurately. Many tumors overexpress RAD51… Read More
SUMMARY Regulatory T cells (Tregs) modulate immune function by preventing autoreactive T cell responses, including those that would normally target cancer cells. Treg activity can significantly limit the efficacy of immunotherapies designed to stimulate CD8+ T cells, and therefore a strategy for reducing Treg activity as an aspect of immunotherapy… Read More
SUMMARY Stabilization of therapeutic proteins and peptides is often necessary to improve pharmacokinetic properties and reduce proteolysis in vivo. However, pre-existing stabilization strategies require expensive catalysts or harsh reagents that prevent preservation of certain sterically challenging protein structures. The inventors found that the Diels-Alder reaction, when performed aqueously or in… Read More
SUMMARY Calcium phosphates have chemical similarity to bones and teeth, and as such, these compounds are highly desired for orthopedic and dental implant applications. However, current formulations have limited bioavailability and compressive strength, which limits the clinical utility of these materials. The inventors developed a method to synthesize polymer stabilized… Read More
SUMMARY An understanding of protein-protein interactions (PPIs) is critical to uncovering new disease pathophysiology and for developing small molecule and antibody treatments. Problematically, current approaches to assay PPIs are limited by sensitivity, signal to noise ratio, and the need to carefully optimize the assay for each new application. The inventors… Read More
SUMMARY Adjuvant radiation therapy post-surgery remains largely ineffective, with just 5% of patients showing a survival benefit. Small molecule JAK inhibitors have shown efficacy in the clinic at treating these patients, yet problematically this approach is plagued by off-target toxicities and eventual development of treatment resistance. The inventors used an… Read More