SUMMARY The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for synthetic biology and gene therapy. The ability to precisely modify DNA sequences within living cells is crucial… Read More
SUMMARY Polymersomes are a type of nanoscale vesicle made from block copolymers and can encapsulate a variety of therapeutic agents including proteins and nucleic acids. These nanovesicles are assembled at room temperature and incorporate features such as permanently charged moieties for stability and mannosylation for targeted delivery. Read More
SUMMARY The technology enhances cytokine signaling and immune function, optimizing the antiviral and anti-cancer efficacy of Type III IFNs by adjusting cytokine-receptor interaction affinity and relative JAK geometry, providing an effective treatment for cancer and viral infections with reduced side effects. The unmet need:… Read More
SUMMARY This technology is a prevention method for those at risk of C. difficile infection using a mutated strain of C. difficile that reduces toxicity and competes with virulent strains, offering a safer alternative to antibiotics and fecal microbiome transplants by colonizing the colon and preventing infections. Read More
SUMMARY Patients with advanced liver disease, transplant recipients, and other critically ill populations frequently experience profound microbiome dysbiosis due to antibiotics and hospitalization. This dysbiosis is characterized by loss of microbial diversity, depletion of beneficial metabolites (e.g., butyrate, secondary bile acids), and overgrowth of pathogenic taxa, which correlates with bloodstream… Read More
SUMMARY Drug-resistant Enterobacteriaceae (particularly K. pneumoniae) are a growing cause of hospital-acquired infections, pneumonia, and antibiotic failure. Broad-spectrum antibiotics exacerbate dysbiosis and resistance, while fecal microbiota transplant lacks standardization, mechanistic clarity, and regulatory scalability. Existing probiotics poorly predictive, leaving a critical gap for precision, reproducible microbiome therapeutics that reliably clear… Read More
SUMMARY Klebsiella infections are a major and growing clinical threat, particularly in hospital-acquired and device-associated settings, where multidrug resistance severely limits antibiotic options. Existing antibiotics disrupt commensal microbiota, drive resistance, and often fail against carbapenem-resistant strains. There is a clear unmet need for pathogen-specific antibacterial strategies that are effective, durable,… Read More
SUMMARY Methicillin-resistant Staphylococcus aureus (MRSA) infection is the leading cause of skin and soft tissue infections that affect nearly 30% of healthy adults. Staph infections can escalate in intensity if introduced to the bloodstream and can lead to sepsis or death. The current treatment of MRSA is partially effective through oxacillin… Read More
SUMMARY TB bacterium, Mycobacterium tuberculosis (M. tuberculosis), is extremely slow growing compared to other bacteria and is naturally resistant to many of the powerful antibiotics that are effective against other bacterial infections. In recent years, multi-drug-resistant TB strains (MDR-TB) have arisen that are resistant to standard treatment and require extensive… Read More
SUMMARY There have been significant research efforts to develop various COVID-19 treatments. Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus i.e. SARS-CoV-2, which has spread rapidly throughout the world and was declared a global pandemic by WHO in March 2020. Nsp15 is… Read More
SUMMARY The SARS-CoV-2 virus spreads by binding its spike protein to the human angiotensin-converting enzyme 2 (hACE2) protein expressed at the cell surface of lungs, arteries, heart, kidney, and intestines. The inventors have developed 12 hydrocarbon stapled peptides that bind to the viral spike protein. Delivered by… Read More
SUMMARY Inventors devised a nanomedicine termed “Nanotraps” that can completely capture and eliminate SARS-CoV-2 by triggering macrophages to engulf and clear the virus without becoming infected. Ex vivo lung perfusion system. Zero toxicity was found in mice as evidenced by histological analysis of heart, liver, spleen, lung, and kidney, as… Read More