Diagnostics Research Tools Therapeutics A Platform for Developing High-Affinity Selective Binding Proteins to Short and Flexible Peptide Motifs Short and flexible peptide motifs such as GPCRs and histone tails are attractive targets for therapeutic development, but the generation of traditional antibodies against… Desired Partnership: Licensing IP: Patent Pending
Other Research Tools Therapeutics Thermonobodies: A Novel Thermostable FN3 Binding Protein Scaffold Monobodies are synthetic binding proteins based off a human fibronectin type 3 (FN3) scaffold that have demonstrated their utility in applications such as the… Interests: Biologics Desired Partnership: Investment, Licensing IP: Patent Issued
Materials Research Tools A Metal Organic Framework (MOF) Containing Nitrogen Donor Ligands For Highly Efficient Catalysis of Organic Reactions Pyridyl moieties are highly useful in catalytic applications because of their robust redox stability, metallic coordination versatility, and functionalization ease. However, their application is… Interests: Chemical Synthesis Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics Library E: Highly Optimized Recombinant Antibody Phage-Display Library Using recombinant antibody libraries for drug development has numerous advantages over animal immunization including: faster production times, favorable expression, and not being limited by… Interests: Antibody, Antibody Desired Partnership: Licensing IP: Tangible property
Research Tools Therapeutics Q11: a Highly Homogeneous Multivalent and Single-component Vaccine Adjuvating Platform There is a limited choice in clinically approved adjuvants for vaccine development. Current solutions are themselves immunogenic, causing injection site swelling and reactions. The… Interests: Biologics, Drug Screening, Infectious Disease Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics A Primary 3D Culture Model for the High Throughput Ex-vivo Modeling of Ovarian Cancer Metastasis Current high throughput screens for ovarian cancer drug discovery use monolayer cell culture on plastic, and problematically cannot accurately model the cross communication between… Interests: Drug Development Tool Desired Partnership: Licensing IP: Tangible property
Research Tools A Sensitive and High Throughput Method for the Rapid Quantification of Radiation Induced DNA Damage Current high throughput assays to quantify radiation induced DNA damage are limited by low sensitivity and cannot reliably detect radiation induced damage lower than… Interests: Imaging Agents Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics Engineered Protein G for Creating Multivalent, Bispecific Recombinant Antibody Affinity Reagents Antibody fragments such as Fabs have demonstrated their utility as research tools, diagnostics, and in therapeutic applications. However, the monovalent nature of Fabs and… Interests: Antibody Desired Partnership: Licensing IP: Patent Pending
Research Tools Therapeutics Small Molecule Metabolism Potentiators That Activate NRF2-Mediated Cytoprotective Transcriptional Programs The KEAP1-NRF2 pathway is implicated in a wide range of diseases and as such, is a highly sought-after drug target. Problematically, past therapeutic approaches… Interests: Small Molecules Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Research Tools Therapeutics Silicon Nanomaterials for Neuronal Cell Activation Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application… Interests: Cardiovascular, Drug Delivery, Drug Screening, Musculoskeletal, Neurology, Ophthalmology Desired Partnership: Licensing IP: Patent Pending
Research Tools Therapeutics Broadly Neutralizing Neuraminidase Antibodies for Prophylactic and Therapeutic Treatment of Influenza One of the weaknesses of current influenza vaccines is seasonable variability in efficacy, which is predominantly caused by escape mutations in the hemagglutinin (HA)… Interests: Antibody, Biologics, Infectious Disease Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools A Neural Network to Quantify in Situ Adaptive Immunity in Autoimmune Disorders Presently, the use of single cell methods such as RNA sequencing can identify rare inflammatory cellular populations that can be used for the diagnosis… Interests: Imaging Desired Partnership: Licensing IP: Patent Pending
