Research Tools OSCA: A System For Efficient Construction Of Adenovirus Vectors Adenoviruses (Ad) are a non-enveloped linear double-stranded DNA viruses with over 50 serotypes identified in humans. They have received significant attention as an in… Interests: Drug Delivery, Drug Development Tool Reference ID: 21-T-143 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Software SCALES: A System For Predicting Interaction And Function In Bacteria Using Co-Variation The current understanding of how proteins interact to create collective functional groups (e.g., complexes, pathways, meta-pathways) is incomplete and difficult to elucidate. Therefore, the… Interests: Microbiology/Virology Reference ID: 21-T-093 Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Research Tools Therapeutics A Platform for Developing High-Affinity Selective Binding Proteins to Short and Flexible Peptide Motifs Short and flexible peptide motifs such as GPCRs and histone tails are attractive targets for therapeutic development, but the generation of traditional antibodies against… Reference ID: 06-T-018 Desired Partnership: Licensing IP: Patent Pending
Other Research Tools Therapeutics Thermonobodies: A Novel Thermostable FN3 Binding Protein Scaffold Monobodies are synthetic binding proteins based off a human fibronectin type 3 (FN3) scaffold that have demonstrated their utility in applications such as the… Interests: Biologics Reference ID: 16-T-034 Desired Partnership: Investment, Licensing IP: Patent Issued
Materials Research Tools A Metal Organic Framework (MOF) Containing Nitrogen Donor Ligands For Highly Efficient Catalysis of Organic Reactions Pyridyl moieties are highly useful in catalytic applications because of their robust redox stability, metallic coordination versatility, and functionalization ease. However, their application is… Interests: Chemical Synthesis Reference ID: 14-T-033 Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics Library E: Highly Optimized Recombinant Antibody Phage-Display Library Using recombinant antibody libraries for drug development has numerous advantages over animal immunization including: faster production times, favorable expression, and not being limited by… Interests: Antibody, Antibody Reference ID: 18-T-651 Desired Partnership: Licensing IP: Tangible property
Research Tools Therapeutics Q11: a Highly Homogeneous Multivalent and Single-component Vaccine Adjuvating Platform There is a limited choice in clinically approved adjuvants for vaccine development. Current solutions are themselves immunogenic, causing injection site swelling and reactions. The… Interests: Biologics, Drug Screening, Infectious Disease Reference ID: 09-T-118 Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics A Primary 3D Culture Model for the High Throughput Ex-vivo Modeling of Ovarian Cancer Metastasis Current high throughput screens for ovarian cancer drug discovery use monolayer cell culture on plastic, and problematically cannot accurately model the cross communication between… Interests: Drug Development Tool Reference ID: 18-T-575 Desired Partnership: Licensing IP: Tangible property
Research Tools A Sensitive and High Throughput Method for the Rapid Quantification of Radiation Induced DNA Damage Current high throughput assays to quantify radiation induced DNA damage are limited by low sensitivity and cannot reliably detect radiation induced damage lower than… Interests: Imaging Agents Reference ID: 08-T-155 Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics Engineered Protein G for Creating Multivalent, Bispecific Recombinant Antibody Affinity Reagents Antibody fragments such as Fabs have demonstrated their utility as research tools, diagnostics, and in therapeutic applications. However, the monovalent nature of Fabs and… Interests: Antibody Reference ID: 14-T-076 Desired Partnership: Licensing IP: Patent Pending
Research Tools Therapeutics Small Molecule Metabolism Potentiators That Activate NRF2-Mediated Cytoprotective Transcriptional Programs The KEAP1-NRF2 pathway is implicated in a wide range of diseases and as such, is a highly sought-after drug target. Problematically, past therapeutic approaches… Interests: Small Molecules Reference ID: 18-T-089 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Research Tools Therapeutics Silicon Nanomaterials for Neuronal Cell Activation Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application… Interests: Cardiovascular, Drug Delivery, Drug Screening, Musculoskeletal, Neurology, Ophthalmology Reference ID: 16-T-038 Desired Partnership: Licensing IP: Patent Pending
