SUMMARY A method that analyzes cfRNA methylation in plasma to distinguish human RNA from microbiome RNA, accurately detecting colorectal cancer through specific methylation markers even in ultralow input samples. The Unmet Need: Effective biomarkers for early detection of colorectal cancer Current advancements… Read More
SUMMARY Sepsis is a systemic response to infection and remains a leading cause of death in intensive care units worldwide while our understanding of the pathogenesis of sepsis across most tissues and organs of the body remains rudimentary. The disease is a global health issue in need of targeted therapies… Read More
SUMMARY Detection and monitoring of autoantibodies against Angiotensin II in COVID-19 patients, guiding diagnosis, treatment, and vaccine design to reduce blood pressure complications and prevent harmful autoimmune responses linked to the virus’s Spike protein The Unmet Need: Novel strategies to understand… Read More
SUMMARY Influenza viruses remain a global health problem, with antigenically drifting seasonal viruses and the constant risk of zoonotic influenza virus spillovers into humans. Antibodies against the major surface glycoprotein hemagglutinin (HA) are critical for providing protection against influenza virus infection. HA is divided into two domains: the globular head… Read More
SUMMARY The current understanding of how proteins interact to create collective functional groups (e.g., complexes, pathways, meta-pathways) is incomplete and difficult to elucidate. Therefore, the current methods used to characterize/identify the hierarchy of proteins in biology are based on an understanding of only a minimal number of cases/examples. Read More
SUMMARY As of February 2021, there have been over 107 million cases and over 2 million deaths caused worldwide by the novel virus SARS-CoV-2. Few vaccination and treatment approaches are currently in use with many in development. The… Read More