Materials Research Tools A Metal Organic Framework (MOF) Containing Nitrogen Donor Ligands For Highly Efficient Catalysis of Organic Reactions Pyridyl moieties are highly useful in catalytic applications because of their robust redox stability, metallic coordination versatility, and functionalization ease. However, their application is… Interests: Chemical Synthesis Reference ID: 14-T-033 Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics Q11: a Highly Homogeneous Multivalent and Single-component Vaccine Adjuvating Platform There is a limited choice in clinically approved adjuvants for vaccine development. Current solutions are themselves immunogenic, causing injection site swelling and reactions. The… Interests: Biologics, Drug Screening, Infectious Disease Reference ID: 09-T-118 Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics A Primary 3D Culture Model for the High Throughput Ex-vivo Modeling of Ovarian Cancer Metastasis Current high throughput screens for ovarian cancer drug discovery use monolayer cell culture on plastic, and problematically cannot accurately model the cross communication between… Interests: Drug Development Tool Reference ID: 18-T-575 Desired Partnership: Licensing IP: Tangible property
Research Tools A Sensitive and High Throughput Method for the Rapid Quantification of Radiation Induced DNA Damage Current high throughput assays to quantify radiation induced DNA damage are limited by low sensitivity and cannot reliably detect radiation induced damage lower than… Interests: Imaging Agents Reference ID: 08-T-155 Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics Engineered Protein G for Creating Multivalent, Bispecific Recombinant Antibody Affinity Reagents Antibody fragments such as Fabs have demonstrated their utility as research tools, diagnostics, and in therapeutic applications. However, the monovalent nature of Fabs and… Interests: Antibody Reference ID: 14-T-076 Desired Partnership: Licensing IP: Patent Pending
Research Tools Therapeutics Small Molecule Metabolism Potentiators That Activate NRF2-Mediated Cytoprotective Transcriptional Programs The KEAP1-NRF2 pathway is implicated in a wide range of diseases and as such, is a highly sought-after drug target. Problematically, past therapeutic approaches… Interests: Small Molecules Reference ID: 18-T-089 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Research Tools Therapeutics Silicon Nanomaterials for Neuronal Cell Activation Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application… Interests: Cardiovascular, Drug Delivery, Drug Screening, Musculoskeletal, Neurology, Ophthalmology Reference ID: 16-T-038 Desired Partnership: Licensing IP: Patent Pending
Research Tools Therapeutics Broadly Neutralizing Neuraminidase Antibodies for Prophylactic and Therapeutic Treatment of Influenza One of the weaknesses of current influenza vaccines is seasonable variability in efficacy, which is predominantly caused by escape mutations in the hemagglutinin (HA)… Interests: Antibody, Biologics, Infectious Disease Reference ID: 18-T-006 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools A Neural Network to Quantify in Situ Adaptive Immunity in Autoimmune Disorders Presently, the use of single cell methods such as RNA sequencing can identify rare inflammatory cellular populations that can be used for the diagnosis… Interests: Imaging Reference ID: 17-T-035 Desired Partnership: Licensing IP: Patent Pending
Research Tools Therapeutics Activity-responsive Split RNA Polymerase Platform for Biosensors and Gene Therapy An understanding of protein-protein interactions (PPIs) is critical to uncovering new disease pathophysiology and for developing small molecule and antibody treatments. Problematically, current approaches… Interests: Biologics, Drug Delivery, Drug Screening, Gene Therapy Reference ID: 16-T-069 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Depalmitoylation Chemical Probes Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and… Interests: Diabetes, Drug Delivery, Drug Screening, Hematology, Infectious Disease, Metabolic Disorders, Neurology, Oncology, Oncology Hematopoietic, Oncology Radiotherapy, Oncology Solid Tumor Reference ID: 16-T-128 Desired Partnership: Co-development, Licensing IP: Patent Issued
Diagnostics Research Tools A Versatile and High-throughput Assay for the Directed Evolution of Reverse Transcriptases to Profile Epigenetic Modifications With NGS Engineered reverse transcriptases (RTs) to profile epigenetic modifications have numerous advantages over traditional antibody enrichment methods including: single base pair resolution, lower sample quantities… Interests: Tangible Property Reference ID: 18-T-669 Desired Partnership: Licensing IP: Tangible property
