Research Tools Therapeutics Context-Specific Cytosine Base Editors For Precise Single-Nucleotide DNA Editing Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with… Interests: Cell Line, Drug Development Tool, Gene Therapy Reference ID: 24-T-089 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Antibody-Based Therapeutics For Inhibiting Growth Hormone Receptor Dimerization And Signaling Antibodies that block growth hormone signaling by binding the receptor or hormone to stop receptor pairing, based on high-affinity, defined sequences for therapeutic and… Interests: Antibody, Rare/Orphan Diseases Reference ID: 23-T-100 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Pan-Specific γ9δ2 T-Cell Antibodies For Activation And Targeted Cancer Immunotherapy A panel of pan-specific Vγ9Vδ2 TCR-recognizing antibodies that allosterically trigger T-cell activation to engage and kill cancer cells, making it highly applicable for targeted… Interests: Antibody, Antibody, Immunotherapy Reference ID: 24-T-215 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Single-Step Method For Assembling Free-Standing Lipid Bilayers In Holey Grids For Cryo-EM Of Membrane Proteins Simplified approach to assemble free-standing lipid bilayers with membrane proteins in holey carbon grids directly usable for cryo-EM with high resolution The Unmet… Reference ID: 24-T-177 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Research Tools Therapeutics Scalable Bioelectronic Production Of Extracellular Vesicles For Regenerative Medicine Bioelectronic devices and methods for the electrical stimulation of cells and engineered tissue for the scalable production of extracellular vesicles for drug delivery and… Interests: Medical, Stem Cell Therapy Reference ID: 23-T-048 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase A novel platform, bacterial deaminase-enabled recoding of RNA (DECOR), utilizing an engineered bacterial adenosine deaminase to achieve programmable adenosine-to-inosine (A-to-I) editing on single-stranded RNA.… Interests: Gene Therapy Reference ID: 24-T-189 Desired Partnership: Co-development, Licensing IP: Patent Pending
Medical Devices Research Tools New Toolkit And Methods For Large-Scale Spatial Transcriptomics Tools and methods to map the entire transcriptome with large-scale histology sections from whole animal or whole human organs with high resolution and sensitivity… Reference ID: 22-T-069 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Novel In Vivo Gene Editing System A engineered OgeuIscB- ωRNA for efficient and precise genome editing with increased potency and specificity while more compact in size compared to other CRISPR-Cas… Reference ID: 23-T-121 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Genetic Engineering Tools To Stimulate And Enhance The Production Of Select Compounds From Bacterial Species Synthetic biology toolsets to genetically manipulate the microbiota, specifically non-model resident gut microbes, to alter gene expression and cellular function to produce therapeutic compounds.… Interests: Gastrointestinal, Immunology, Inflammatory, Metabolic Disorders, Microbiome Reference ID: 23-T-162 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Exploiting Chromosomal Passenger Complex (CPC) Proteins For Immunotherapeutic Applications Cell division is a fundamental biological process, ensured to be of high fidelity by the Chromosome Passenger Complex (CPC), a crucial protein complex involved… Interests: Antibody, Antibody Reference ID: 22-T-035 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Optogenetic Protein Fusion for Precise And Low-Impact Actin Cytoskeleton Imaging In Cells A light-sensitive version of LifeAct, a peptide used to label actin in cells, to reduce its harmful side effects by controlling its binding through… Interests: Imaging Reference ID: 21-T-126 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Other Research Tools A New Method of Isotope Enrichment and Separation: Preferential Embedding of Heavier Isotopes Into Ices Isotope separation methods are key to numerous scientific and industrial processes. Nuclear power plants and weapons, for example, require fuels enriched in a select… Interests: Chemical Synthesis, Electronic, Medical Reference ID: 21-T-042 Desired Partnership: Co-development, Licensing IP: Patent Pending
