Materials Research Tools Enzyme-Triggered Acylation Probes for Spatial RNA Labeling Enhanced spatial RNA labeling accuracy and efficiency through bioorthogonal acylating agents that enable precise proximity-dependent RNA modification and imaging, improving cellular RNA mapping for… Interests: Chemical Synthesis, Drug Development Tool, Tangible Property Reference ID: 24-T-225
Therapeutics Nanoparticle Delivery of Stabilized Synthetic Transcriptional Repressors for Targeted Gene Regulation Enhanced control of disease-associated gene expression through nanoparticle delivery of stabilized DNA-binding peptides and miniproteins, improving targeted transcriptional regulation The Unmet Need: Efficient and specific… Interests: Drug Delivery Reference ID: 23-T-156
Therapeutics Covalent Pan-Kinase Inhibitors and Live-Cell Activity Probes A cell-permeable, covalent multikinase activity probe that enhances selective kinase detection in native cellular environments, enabling precise profiling of kinase targets and inhibitor engagement… Interests: Cardiovascular, Dermatology, Inflammatory, Neurology, New Chemical Entity, Oncology Reference ID: 25-T-024
Research Tools Therapeutics Context-Flexible Cytosine Base Editing Using An Evolved Riboflavin-Pathway Deaminase Enhanced precision in cytosine base editing by employing an evolved riboflavin biosynthesis enzyme RibD that converts targeted cytosines to thymines without intrinsic sequence-context specificity,… Interests: Gene Therapy Reference ID: 25-T-022
Therapeutics Endothelium-Targeted mRNA Therapeutics For Acute And Chronic Vascular Disease Targeted delivery of therapeutic mRNA to inflamed vascular endothelial cells, achieving localized reduction of vascular inflammation and arterial plaque formation to improve treatment outcomes… Interests: Autoimmune, Cardiovascular, Inflammatory Reference ID: 22-T-182
Therapeutics A Precision Nanomedicine Platform For Pulmonary And Organ Fibrosis A targeted nanomedicine platform for delivering therapeutics to activated fibroblasts in pulmonary fibrosis and other fibrotic diseases The Unmet Need: Current pulmonary fibrosis therapies… Interests: Pulmonary Reference ID: 20-T-082
Therapeutics Targeted mRNA Nanomedicine for ARDS and Ventilator-Induced Lung Injury A targeted nanomedicine platform improves acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) outcomes by selectively delivering therapeutic mRNA to inflamed pulmonary… Interests: Autoimmune, Inflammatory, Pulmonary Reference ID: 22-T-183
Diagnostics Software Slide-Level Uncertainty Quantification For Deep Learning Predictions In Digital Histopathology. The technology improves diagnostic accuracy in digital histopathology by providing slide-level uncertainty quantification for deep learning predictions, enabling more reliable and actionable clinical decision-making… Reference ID: 23-T-021
Diagnostics Therapeutics Tumor Aneuploidy Score As A Predictor Of Immunotherapy Response Tumor aneuploidy scoring delivers improved immunotherapy response prediction, enhancing personalized cancer treatment by providing prognostic insights beyond existing biomarkers like tumor mutational burden. The… Reference ID: 23-T-172
Diagnostics Research Tools Integration Of Semiconductor-Based Components And Functionality Into Soft Microfluidics For Cell Lysis And Other Biological Applications This technology delivers precise and scalable cellular content extraction for genomic analyses by integrating semiconductor-based piezoelectric sharp tip arrays into soft microfluidics, enabling efficient… Reference ID: 21-T-034
Research Tools Conformation-Specific HLA-F Antibodies Enable Next-Generation Immune Profiling A panel of antibody-based reagents has been developed to distinguish two conformational states of the nonclassical MHC protein HLA-F: an open conformer form and… Interests: Antibody, Biomarker, Drug Development Tool Reference ID: 22-T-062
Therapeutics Novel TET2-Targeting Approaches to Induce Fetal Hemoglobin in Sickle Cell Disease and Thalassemia This technology enables increased fetal hemoglobin production to alleviate symptoms of blood disorders by modulating TET2 enzyme activity through targeted mutation and pharmacological suppression.… Reference ID: 24-T-028
