Therapeutics Therapeutic Exosomes for Multiple Sclerosis and Other Demyelinating Diseases Multiple Sclerosis (MS) is caused by degradation of the protective myelin sheath that surrounds nerve fibers in the brain and spinal cord. Current MS… Interests: Neurology Reference ID: 12-T-060 Desired Partnership: Co-development, Investment, Licensing IP: Patent Issued
Research Tools Therapeutics Small Molecule Metabolism Potentiators That Activate NRF2-Mediated Cytoprotective Transcriptional Programs The KEAP1-NRF2 pathway is implicated in a wide range of diseases and as such, is a highly sought-after drug target. Problematically, past therapeutic approaches… Interests: Small Molecules Reference ID: 18-T-089 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Research Tools Therapeutics Silicon Nanomaterials for Neuronal Cell Activation Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application… Interests: Cardiovascular, Drug Delivery, Drug Screening, Musculoskeletal, Neurology, Ophthalmology Reference ID: 16-T-038 Desired Partnership: Licensing IP: Patent Pending
Materials Medical Devices A Surgical Stent for Impermeable Anastomoses Anastomotic leak is a serious complication of gastrointestinal surgery, with consequences ranging from benign to life threatening. Treatment is costly and exposes patients to… Interests: Gastrointestinal Reference ID: 18-T-091 Desired Partnership: Licensing IP: Patent Pending
Therapeutics FOXP3 Stapled Peptides to Deactivate Regulatory T Cells Regulatory T cells (Tregs) modulate immune function by preventing autoreactive T cell responses, including those that would normally target cancer cells. Treg activity can… Interests: Biologics, Immunotherapy, Oncology, Oncology Hematopoietic, Oncology Solid Tumor Reference ID: 16-T-107 Desired Partnership: Co-development, Licensing IP: Patent Issued
Therapeutics Self-assembling Nanofibril Particles for Controlled Release of IV and SUBQ Therapeutics Clinically approved methods for the controlled release of oral therapies have demonstrated their efficacy in reducing required dosage, administration frequency, and side effects, thereby… Interests: Drug Delivery Reference ID: 15-T-079 Desired Partnership: Licensing IP: Patent Pending
Materials Medical Devices Therapeutics Silicon Mesh for the Remote Modulation of Organ Electrical Activity Electric organ stimulation has shown promise in the clinic for treating aberrant neurological and cardiac activity. Problematically, this approach is limited by the high… Interests: Cardiovascular, Neurology, Psychiatry Reference ID: 18-T-046 Desired Partnership: Licensing IP: Patent Pending
Medical Devices Software Therapeutics Computational Method to Design Simultaneous Radiation Treatment of Multiple Metastatic Lesions Stereotactic ablative body radiotherapy (SART) is the precise delivery of concentrated radiation beams to a tumor from different angles. Due to the cross interaction… Interests: Healthcare IT, Oncology, Oncology Radiotherapy, Oncology Solid Tumor Reference ID: 18-T-079 Desired Partnership: Co-development, Investment, Licensing IP: Patent Pending
Therapeutics Novel Aqueous Chemical Stabilization Method for Proteins Based on the Diels-alder Reaction Stabilization of therapeutic proteins and peptides is often necessary to improve pharmacokinetic properties and reduce proteolysis in vivo. However, pre-existing stabilization strategies require expensive… Interests: New Chemical Entity Reference ID: 19-T-050 Desired Partnership: Licensing IP: Patent Pending
Therapeutics Immune Modulatory Small Molecules for the Treatment of Sepsis and Autoimmune Diseases Tumor necrosis factor alpha (TNFα) is an important cytokine that activates cell death programs in response to acute inflammation. TNFα inhibitors are currently used… Interests: Infectious Disease, Neurology Reference ID: 15-T-040 Desired Partnership: Licensing IP: Patent Pending
Research Tools Therapeutics Broadly Neutralizing Neuraminidase Antibodies for Prophylactic and Therapeutic Treatment of Influenza One of the weaknesses of current influenza vaccines is seasonable variability in efficacy, which is predominantly caused by escape mutations in the hemagglutinin (HA)… Interests: Antibody, Biologics, Infectious Disease Reference ID: 18-T-006 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Other Therapeutics Injectable Calcium Phosphate Amorphous Nanoparticle Pastes for Orthopedic Applications Calcium phosphates have chemical similarity to bones and teeth, and as such, these compounds are highly desired for orthopedic and dental implant applications. However,… Interests: Musculoskeletal Reference ID: 15-T-127 Desired Partnership: Co-development, Licensing IP: Patent Pending
