Research Tools Technology Classifications Therapeutics Bioorthogonal Enzyme-Probe System For Spatially Specific Biomolecule Labeling Novel proximity labeling technology utilizes a bioorthogonal protecting group, impervious to endogenous esterases, paired with evolved BS2 esterase mutants. The enzyme-mediated unmasking creates a… Interests: Drug Development Tool Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Site-Directed RNA Editing Technology As A Novel Analgesic Use of RNA editing to modify NaV1.7 sodium channels in nociceptors, making them permeable to Na+ and K+ ions reducing the excitability of these… Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Therapeutics Ketone Carbonyl Atom Swap Platform For Drug Discovery And Lead Optimization A two-step chemical process using a special reagent to swap a ketone's oxygen atom with a sulfur atom creating new compounds, particularly useful for… Interests: Chemical Synthesis, Chemical Synthesis Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Context-Specific Cytosine Base Editors For Precise Single-Nucleotide DNA Editing Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with… Interests: Cell Line, Drug Development Tool, Gene Therapy Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics CD200-Antigen Fusion Proteins For Myeloid-Targeted Antigen-Specific Immune Tolerance CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance… Interests: Allergy, Autoimmune, Drug Development Tool, Inflammatory Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Gene Splice-Switching Technology for Treating CACNA1A-Associated Neurological Diseases This technology regulates the expression of the CACNA1A gene, which encodes a neuronal calcium channel subunit, by redirecting alternative splicing to treat related neurological… Interests: Musculoskeletal, Neurology, Rare/Orphan Diseases Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Engineered Mutator tRNAs For Correcting Missense Genetic Defects And Inducing Cancer Cell Death Engineered tRNAs with altered anticodons and chemical modifications deliver the correct amino acid at mutated codons to restore protein function in genetic diseases or… Interests: Biologics, Oncology Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Low-Input Methylation Sequencing For Profiling Epitranscriptomic Signatures And Early Colorectal Cancer Diagnosis A method that analyzes cfRNA methylation in plasma to distinguish human RNA from microbiome RNA, accurately detecting colorectal cancer through specific methylation markers even… Interests: Epigenetics, Microbiology/Virology, Sequencing Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Antibody-Based Therapeutics For Inhibiting Growth Hormone Receptor Dimerization And Signaling Antibodies that block growth hormone signaling by binding the receptor or hormone to stop receptor pairing, based on high-affinity, defined sequences for therapeutic and… Interests: Antibody, Rare/Orphan Diseases Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Computerized Adaptive Testing System For Real-Time Multidimensional Fatigability Assessment A computerized adaptive test using a bifactor model on tablet devices to measure fatigue relative to activity delivering personalized, real-time insights by integrating with… Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Synthetic Monoclonal Antibodies For Blocking Human Growth Hormone Receptor Signaling Synthetic monoclonal antibodies using phage display to bind and block the human growth hormone receptor, potentially offering a more potent and specific treatment for… Interests: Antibody, Rare/Orphan Diseases Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Software Computational Framework For Unraveling Single-Cell Transcriptional Dynamics Novel system using statistical topic modeling and a bursty transcriptional model to analyze spliced and unspliced RNA, revealing precise cell state transitions and dynamics… Desired Partnership: Co-development, Licensing IP: Patent Pending
