Medical Devices Therapeutics Hydrogel Electrochemical Platform For Controlled Localized Hydrogen Delivery A portable device that generates and stores molecular hydrogen within a hydrogel using electrodes to precisely deliver hydrogen locally to treat oxidative stress in… Interests: Dermatology Reference ID: 25-T-093 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Type I Interferons For Enhancing Chimeric Antigen Receptor T-Cell Efficacy Method to enhance CAR T-cell efficacy by incorporating low-dose exogenous IFN-α2 into CD19-directed, CD28-costimulated CAR T cells post-transduction during manufacturing boosting cytolytic molecule expression,… Interests: Immunooncology, Immunotherapy, Oncology Reference ID: 25-T-065 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Conformation-Specific Genetically Encodable Intrabodies for Spatially Modulating Protein Kinase Signaling Genetically encoded synthetic antibody fragments, expressed intracellularly, to specifically bind the mTOR FKBP12-Rapamycin binding domain inhibiting mTORC1 and mTORC2 activity. Fused with localization signals,… Interests: Antibody, Drug Development Tool Reference ID: 25-T-060 Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Research Tools A High-Throughput, Label-Free Microfluidic System For Combinatorial Droplet Generation, Storage, And Analysis A microfluidic platform consisting of a two-layer PDMS system that generates and stores combinatorial droplets, enabling high-throughput screening with an integrated label-free, image-based detection… Reference ID: 25-T-014 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Peripherally Restricted Κ-Opioid Receptor Agonist Co-Formulation For Preventing Opioid-Induced Respiratory Depression An opioid painkiller combined with a peripherally restricted κ-opioid receptor agonist stimulating the carotid body to prevent opioid-induced respiratory depression, enhancing breathing without affecting… Interests: Small Molecules Reference ID: 25-T-071 Desired Partnership: Co-development, Licensing IP: Patent Pending
Medical Devices A Wearable Bioelectronic Patch For Controlling Bacterial Pathogens Without Antibiotics A wearable patch using an acidic hydrogel and low-voltage electricity to safely reduce harmful bacteria on skin. The bioelectric system sensitizes bacteria, then modulates… Reference ID: 25-T-029 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for… Interests: Biologics, Gene Therapy, Infectious Disease, Tangible Property Reference ID: 25-T-198 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Bioorthogonal Enzyme-Probe System For Spatially Specific Biomolecule Labeling Novel proximity labeling technology utilizes a bioorthogonal protecting group, impervious to endogenous esterases, paired with evolved BS2 esterase mutants. The enzyme-mediated unmasking creates a… Interests: Drug Development Tool Reference ID: 25-T-114 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Site-Directed RNA Editing Technology As A Novel Analgesic Use of RNA editing to modify NaV1.7 sodium channels in nociceptors, making them permeable to Na+ and K+ ions reducing the excitability of these… Reference ID: 23-T-068 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials Ketone Carbonyl Atom Swap Platform For Drug Discovery And Lead Optimization A two-step chemical process using a special reagent to swap a ketone's oxygen atom with a sulfur atom creating new compounds, particularly useful for… Interests: Chemical Synthesis, Chemical Synthesis Reference ID: 25-T-072 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics Context-Specific Cytosine Base Editors For Precise Single-Nucleotide DNA Editing Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with… Interests: Cell Line, Drug Development Tool, Gene Therapy Reference ID: 24-T-089 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics CD200-Antigen Fusion Proteins For Myeloid-Targeted Antigen-Specific Immune Tolerance CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance… Interests: Allergy, Autoimmune, Drug Development Tool, Inflammatory Reference ID: 24-T-085 Desired Partnership: Co-development, Licensing IP: Patent Pending
