SUMMARY Engineered T cells to release cancer-killing proteins only when activated by targeted radiation, enabling precise, localized tumor treatment while minimizing side effects and improving the effectiveness of CAR-T therapy for solid tumors The Unmet Need: Precise spatial and temporal delivery of… Read More
SUMMARY Method to enhance CAR T-cell efficacy by incorporating low-dose exogenous IFN-α2 into CD19-directed, CD28-costimulated CAR T cells post-transduction during manufacturing boosting cytolytic molecule expression, cytokine secretion, and cytotoxicity while minimizing apoptosis The Unmet Need: Enhanced CAR T-cell effector function through modulation… Read More
SUMMARY Nutraceutical approach using specific fatty acids naturally found in human breast milk incorporated into infant formula enhancing immune defense in both neonates and adults The Unmet Need: Solutions for effectively bridging maternal and infant health and immune development through diet The field… Read More
SUMMARY A method to utilize trans-vaccenic acid to enhance CD8+ T cell-mediated anti-tumor immunity through an innovated mechanism promoting T cell activation, infiltration, and survival while reducing exhaustion markers The Unmet Need: Effective immune modulation in the face of multifaceted resistance mechanisms The… Read More
SUMMARY Novel RNA editing method to generate a multitude of neoantigens in tumor cells making the cells more recognizable by T cells and enhancing the efficacy of immune checkpoint inhibitors The problem: Current approaches to further enhance the immunogenicity of tumors fail to… Read More
SUMMARY A major attention of vaccine adjuvant development has been focused on development of robust antibody-mediated protection against pathogens. However, such adjuvants have failed to elicit a robust T-cell mediated protection and are thus found to be less efficacious against diseases like malaria, tuberculosis, Ebola and Zika or in immunotherapy. Read More
SUMMARY There have been significant research efforts to develop effective vaccines that elicit a strong and durable T cell response against intracellular pathogens and cancer. A popular strategy has been to enhance vaccination efficacy by targeting dendritic cells (DCs). For DCs, functional heterogeneity is critical in the complex process of… Read More
SUMMARY Radiotherapy and immunotherapy are used to treat many cancer types, yet only 50% and 20% of patients respond, respectively. Resistance to therapy presents a large problem. N6-methyladenosine (m6A) modification is commonly found in on RNA in eukaryotic cells. By binding to m6A sites, YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein… Read More