SUMMARY An implantable bioelectronic device platform enabling targeted, programmable inhibition of neural activity through lithium ion delivery, offering durable local anesthesia and pain relief without systemic toxicity The Unmet Need: Programmable pain management and local anesthesia solutions featuring targeted delivery and durable… Read More
Summary This technology enables multi-material image reconstruction from conventional single-spectrum X-ray tomography data, including standard CT and tomosynthesis, without requiring dual-energy CT or photon-counting CT hardware. The approach can generate basis-material images and virtual monochromatic images from data acquired using standard X-ray… Read More
SUMMARY The platform delivers ultra-low intensity, wireless, fully implantable photostimulation for deep tissue targets (nerves, heart, diaphragm). It spatially separates light harvesting from bioelectrical stimulation, enabling minimally invasive, leadless, genetic-modification-free interventions. The Unmet Need: Fully implantable, wireless, and low-power devices that can… Read More
SUMMARY A plasmon-enhanced hierarchical gold–titania (Au-TiO₂) Schottky junction biointerface designed for wireless, energy-efficient biological stimulation (neuromodulation, cardiac pacing), real-time biosensing, and minimally invasive artificial vision. The platform is scalable, CMOS-free, and highly robust against biological degradation. The Unmet Need: New semiconductors… Read More
SUMMARY A novel high-resolution mapping platform offering real-time blockline angle, crossing point analytics, and fiber orientation visualization to enable targeted arrhythmia intervention and improved ablation outcomes. The Unmet Need: Current mapping systems lack resolution and analytical depth to pinpoint critical arrhythmogenic regions,… Read More
SUMMARY Lentiviral display platform engineered to directly select and enrich antibodies based on their ability to induce receptor-mediated endocytosis, thereby streamlining the discovery of highly internalizing candidates for targeted therapies The Unmet Need: Efficient discovery platforms that directly select internalizing antibodies for… Read More
Summary University of Chicago researchers have developed a wearable electro-tactile feedback technique that creates touch sensations across the palm and fingers without placing electrodes directly on the palm. By positioning electrodes on the back of the hand and wrist, the system preserves… Read More
SUMMARY This technology uses advanced machine learning algorithms to extract significantly more information from single-photon detector signals than conventional approaches. By analyzing full detector waveforms in real time, the technology improves photon classification, identifies photon properties such as wavelength and polarization, and enables… Read More
SUMMARY NeuroSight ICP is a bedside-ready, AI-assisted forecasting system designed to predict intracranial pressure (ICP) crises roughly 30 minutes before onset using continuous neuro-monitoring data. It combines interpretable statistical modeling with Hidden Markov Model (HMM)-aware features to generate actionable risk scores and alerts… Read More
SUMMARY The CIRTS-4GT3 platform is a compact, programmable system that uses guide RNAs and human protein domains to boost production of specific proteins in cells, offering a safe and targeted therapy for genetic disorders caused by insufficient protein levels The Unmet Need:… Read More
SUMMARY Method to attach butyrate to amino acids, allowing it to bypass gut metabolism and enter the bloodstream, increasing its bioavailability and enabling effective treatment of inflammatory, immune, and neurological conditions throughout the body, including the brain The Unmet Need: Methods to… Read More
SUMMARY Inrich-seq is a new method that selectively enriches and sequences inosine-containing DNA or RNA, enabling highly sensitive, genome-wide detection of off-target effects from adenine base editing in human cells The Unmet Need: Techniques need to rigorously evaluate and profile any unintended… Read More