web analytics

Simultaneous Acquisition of Myocyte Oxygen Usage and Cardiac Strain Data in a Single MRI Scan

Published:
Lead Inventor: Keigo Kawaji
Print or Save to PDF

SUMMARY

  • Abnormal myocardial oxygen usage can predict heart attack or heart transplant rejection before the onset of clinical symptoms. However, there are currently no robust and reliable methods for globally measuring myocardial oxygen use and tissue strain despite the capability of this diagnostic tool to offer patients earlier access to lifesaving care.
  • The inventors have developed an MRI method to quantify global myocardial oxygen usage and tissue strain based on differences in transient magnetic susceptibility between oxygenated and non-oxygenated hemoglobin.
  • The method allows for the simultaneous acquisition of myocardial oxygen consumption data, cardiac strain data, and anatomical imaging in a single breath hold scan on pre-existing MRI equipment. The MRI test results are an image of the patient’s heart with overlaid oxygen usage and strain data in a format that is easy to interpret.
  • In a proof-of-concept study, the inventors demonstrated the capability of their MRI pulse sequence to gather two independent datasets as well as anatomical images in a single breath hold scan.

 

ADVANTAGES

ADVANTAGES

  • Quantitative measurement of myocyte oxygen usage
  • Two types of data acquired in single scan
  • Detects heart attack or graft rejection before symptom onset
  • Method works with existing MRI systems
  • Results easy to read and interpret

 

APPLICATIONS

  • Cardiac imaging and diagnostics
  • Research tool

 

 

 

 

 

  • PCT/US2018/050074