SUMMARY Using recombinant antibody libraries for drug development has numerous advantages over animal immunization including: faster production times, favorable expression, and not being limited by antigen immunogenicity. However, this approach is limited by the significant effort and resources required to generate such a library. The inventors developed a novel 10^10… Read More
SUMMARY Current high throughput screens for ovarian cancer drug discovery use monolayer cell culture on plastic, and problematically cannot accurately model the cross communication between the cancer cells and the tumor microenvironment that occur in vivo. The lack of effective models for ovarian cancer drug screening is responsible for the… Read More
SUMMARY Engineered reverse transcriptases (RTs) to profile epigenetic modifications have numerous advantages over traditional antibody enrichment methods including: single base pair resolution, lower sample quantities needed, and lower noise and background interference. Problematically, current RT engineering strategies are cumbersome, low throughput, and cannot be versatilely applied to multiple types of… Read More