Real-Time High-Definition Mapping Platform For Complex Cardiac Arrhythmia Intervention

SUMMARY

A novel high-resolution mapping platform offering real-time blockline angle, crossing point analytics, and fiber orientation visualization to enable targeted arrhythmia intervention and improved ablation outcomes.

The Unmet Need: Current mapping systems lack resolution and analytical depth to pinpoint critical arrhythmogenic regions, limiting procedural efficacy

• Atrial fibrillation and other complex cardiac arrhythmias remain significant clinical challenges due to limitations in accurately identifying the underlying arrhythmogenic substrate. Current electroanatomical mapping technologies often fail to resolve critical reentrant loops and block line crossings, resulting in incomplete or suboptimal ablation treatment and high recurrence rates. There is a critical need for advanced tools that can provide a more granular and actionable map of the electrical substrate contributing to arrhythmic events.

The Proposed Solution: A novel high-resolution mapping platform to enable targeted arrhythmia intervention and improved ablation outcomes

• The faculty inventor developed a high-resolution intracardiac mapping system that records and visualizes critical regions responsible for arrhythmias, including atrial fibrillation, on a 3D heart geometry. The system utilizes a dense array of electrodes (2.5 mm spacing, 130 channels) and incorporates novel algorithms for block line angle histogram analysis, detection of crossing points, and real-time visualization of fiber orientation. This approach allows for the identification of previously undetectable small and complex reentrant circuits and enables precise localization of substrate characteristics correlated with arrhythmia recurrence, such as myocardial fiber orientation and regions of slow conduction.

ADVANTAGES

ADVANTAGES

• Delivers the highest spatial resolution currently available in electroanatomical mapping (2.5 mm electrode spacing)

• Detects and maps critical arrhythmogenic substrate regions in real time, including crossing points of block lines

• Provides actionable mechanistic insights into myocardial fiber orientation and slow conduction areas

• Supports more effective and precise ablation, with the potential to reduce recurrence rates

• Extensible as a standalone or integrated module for use in clinical or research settings

APPLICATIONS

• Clinical guidance for catheter ablation of atrial fibrillation and other arrhythmias

• Advanced substrate mapping to refine ablation targets and improve procedural outcomes

• Research applications in cardiac electrophysiology, fibrosis mapping, and myocardial fiber analysis

• Integration with existing and next-generation mapping catheters and EP lab software platforms

• Algorithm and hardware validated in preclinical studies; ready for OEM integration, clinical pilot studies, and industry partnership