Summary This technology enables multi-material image reconstruction from conventional single-spectrum X-ray tomography data, including standard CT and tomosynthesis, without requiring dual-energy CT or photon-counting CT hardware. The approach can generate basis-material images and virtual monochromatic images from data acquired using standard X-ray… Read More
SUMMARY A novel high-resolution mapping platform offering real-time blockline angle, crossing point analytics, and fiber orientation visualization to enable targeted arrhythmia intervention and improved ablation outcomes. The Unmet Need: Current mapping systems lack resolution and analytical depth to pinpoint critical arrhythmogenic regions,… Read More
SUMMARY A deep learning tool that quickly and accurately estimates prostate tissue composition from MRI scans, combining physical modeling and AI to provide robust, non-invasive cancer diagnostics without needing large, labeled datasets The Unmet Need: Advanced imaging techniques that can rapidly and… Read More
SUMMARY Lithium-ion batteries have revolutionized portable electronics, but there remains room for improvement in energy density, electrochemical stability, and usable temperature window. An improvement in electrolytes can further such needs for the next-generation Li-ion battery. Current state of the art… Read More
SUMMARY The invention is a novel synthetic approach for surface modification of two-dimensional (2D) metal carbides (MXenes) using molten inorganic salts. Surface modification of MXenes have been hypothesized to affect material aspects ranging from structural properties to electron transport but—prior to this invention—no experimental method existed to… Read More
SUMMARY Electrodes in supercapacitor devices (computers, electric/fossil fuel burning vehicles, and renewable energy storage) and electrodes in lithium (Li) and sodium (Na) batteries (portable electronic devices, grid energy storage applications, and electric vehicles) can all benefit from improvements in their ability to store/produce energy/charge in a more efficient and… Read More
SUMMARY With the increased prevalence of smart devices that monitor speech, such as Alexa and Google Assistant, microphone jamming has become an area of increasing consumer interest. However, current jammers require users to point the jammer in the direction of the microphone, which limits their utility since the location of… Read More
SUMMARY Monobodies are synthetic binding proteins based off a human fibronectin type 3 (FN3) scaffold that have demonstrated their utility in applications such as the modification of enzyme specificity and therapeutics for topologically challenging targets. Thermostability limits shelf life, oral bioavailability in therapeutic applications, and high temperature industrial reaction engineering… Read More
SUMMARY Multiple Sclerosis (MS) is caused by degradation of the protective myelin sheath that surrounds nerve fibers in the brain and spinal cord. Current MS therapies only stop the progression of this demyelination and do not promote the repair of the myelin sheath, which significantly limits their efficacy. The invention… Read More
SUMMARY Stereotactic ablative body radiotherapy (SART) is the precise delivery of concentrated radiation beams to a tumor from different angles. Due to the cross interaction between beams, SART is rarely able to be applied in the simultaneous treatment of multiple metastatic lesions, despite the potential benefit to patients who have… Read More
SUMMARY Vaccine efficacy is limited due to the inability to deliver in-tact antigens to antigen presenting (APC) dendritic cells (DCs) while simultaneously activating the cells in a non-toxic fashion. Adjuvants have been used in an attempt to overcome the issues of vaccine efficacy, however they are poorly soluble which results… Read More
SUMMARY Fine tuning enzyme specificity is desired for industrial catalysis. Enzymes lacking structural characterization or favorable recombinant expression are not amenable to traditional directed evolution or de novo design approaches. “Monobodies” are synthetic binding proteins based off a human FN3 scaffold. When Monobodies bind allosterically near the enzyme active site,… Read More