SUMMARY TB bacterium, Mycobacterium tuberculosis (M. tuberculosis), is extremely slow growing compared to other bacteria and is naturally resistant to many of the powerful antibiotics that are effective against other bacterial infections. In recent years, multi-drug-resistant TB strains (MDR-TB) have arisen that are resistant to standard treatment and require extensive… Read More
SUMMARY There have been significant research efforts to develop various COVID-19 treatments. Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus i.e. SARS-CoV-2, which has spread rapidly throughout the world and was declared a global pandemic by WHO in March 2020. Nsp15 is… Read More
SUMMARY Embryonic and fetal hemoglobin have a higher affinity for oxygen than their adult counterpart, and as such, gene editing techniques to revert red blood cells to produce infant or fetal hemoglobin are being explored for the treatment of sickle cell anemia. Problematically, these techniques require the use of toxic… Read More
SUMMARY Post-CPR cardiogenic shock is associated with hemodynamic instability and poor neurological outcomes. The pathophysiology is unknown and current treatment approaches merely restore basal cardiac function and do not protect against longer term damage. The inventors demonstrated that the main mechanism leading to post-CPR cardiogenic shock is myocardial stunning, which… Read More
SUMMARY Optimized small-molecule inhibitors of RAD51 that selectively suppress D-loop formation and homologous recombination The Unmet Need: Selective agents that suppress homologous recombination repair without off-target toxicity. RAD51 is a central protein in homologous recombination, a DNA repair pathway that helps cells repair double-strand breaks accurately. Many tumors overexpress RAD51… Read More
SUMMARY Airway remodeling induced by asthma and fibrosis promotes reduced responsiveness to currently available therapies. As such, there is an urgent need for the development of novel treatments that target the underlying molecular mechanisms of tissue remodeling in asthma and fibrosis. The inventors discovered a novel class of organic molecule… Read More
SUMMARY The KEAP1-NRF2 pathway is implicated in a wide range of diseases and as such, is a highly sought-after drug target. Problematically, past therapeutic approaches failed due to safety and toxicity of electrophilic NRF2 activators. The inventors developed a novel strategy to indirectly activate NRF2 using a non-covalent metabolism modulating… Read More