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Library E: Highly Optimized Recombinant Antibody Phage-Display Library

SUMMARY Using recombinant antibody libraries for drug development has numerous advantages over animal immunization including: faster production times, favorable expression, and not being limited by antigen immunogenicity. However, this approach is limited by the significant effort and resources required to generate such a library. The inventors developed a novel 10^10… Read More

Depalmitoylation Chemical Probes

SUMMARY Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation, the regulation of the enzymes that control it is poorly understood. The inventors designed an enzyme substrate analogue probe… Read More