Hematology

Novel Use of a Bet Bromodomain Protein Inhibitor (JQ1) for the Treatment of Sickle Cell Anemia and Thalassemia

SUMMARY Embryonic and fetal hemoglobin have a higher affinity for oxygen than their adult counterpart, and as such, gene editing techniques to revert red blood cells to produce infant or fetal hemoglobin are being explored for the treatment of sickle cell anemia. Problematically, these techniques require the use of toxic… Read More

Depalmitoylation Chemical Probes

SUMMARY Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation, the regulation of the enzymes that control it is poorly understood. The inventors designed an enzyme substrate analogue probe… Read More