Hematology

Novel Use of a Bet Bromodomain Protein Inhibitor (JQ1) for the Treatment of Sickle Cell Anemia and Thalassemia

SUMMARY Burn injuries are among the most devastating of all injuries and are the fourth most common type of trauma worldwide.  In the United States, there are 1.1 million burn injuries which require medical attention each year.  These injuries often result in significant scarring having a negative impact on the… Read More

Depalmitoylation Chemical Probes

SUMMARY Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation, the regulation of the enzymes that control it is poorly understood. The inventors designed an enzyme substrate analogue probe… Read More