Drug Repurposing

Method To Use Low-Dose Tocilizumab To Treat Sickle Cell Disease

SUMMARY Sickle cell disease (SCD) is a rare genetic disease that affects red blood cells, predominantly seen in African-American patients. Patients with SCD often have various complications, including acute chest syndrome (ACS), a life-threatening condition similar to pneumonia but unique to SCD. ACS is not entirely understood, and there are no… Read More

Novel Use of a Bet Bromodomain Protein Inhibitor (JQ1) for the Treatment of Sickle Cell Anemia and Thalassemia

SUMMARY Embryonic and fetal hemoglobin have a higher affinity for oxygen than their adult counterpart, and as such, gene editing techniques to revert red blood cells to produce infant or fetal hemoglobin are being explored for the treatment of sickle cell anemia. Problematically, these techniques require the use of toxic… Read More