Therapeutics Small Molecule Therapeutics For Inhibiting Carotid Body Hypersensitivity To Treat Sleep-Related Breathing Disorders New compounds that inhibit an enzyme to reduce hydrogen sulfide in the carotid body, helping to normalize breathing and prevent sleep apnea by targeting… Interests: Small Molecules Reference ID: 16-T-123 Desired Partnership: Co-development, Licensing IP: Patent Issued
Therapeutics Lymphangiogenesis For Therapeutic Immunomodulation A vaccine platform that uses engineered lymphangiogenesis factors and antigens to stimulate lymphatic endothelial cells, creating strong, long-lasting immune memory or tolerance with fewer… Interests: Biologics, Immunotherapy, Oncology Reference ID: 16-T-059 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics A Gene-Modified T Cell Platform For Spatially Controlled Therapeutic Protein Delivery In Response To Radiation Engineered T cells to release cancer-killing proteins only when activated by targeted radiation, enabling precise, localized tumor treatment while minimizing side effects and improving… Interests: Immunooncology, Oncology, Oncology Radiotherapy Reference ID: 24-T-191 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics A Non-Hormonal Therapeutic Platform For Targeting M6A Regulators To Treat Uterine Fibroids A non-hormonal therapeutic strategy for uterine fibroids targeting the upregulated m6A regulator METTL3 employing small molecule inhibitors thereby reducing fibroid cell proliferation and increasing… Interests: Reproductive Health, Small Molecules, Urology Reference ID: 22-T-077 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Novel RNA Replicon Vector For Efficient Gene Delivery To The Skin A Sindbis virus-based self-amplifying RNA vector has been engineered for long-lasting, safe gene expression in skin cells, aiming to treat genetic skin disorders like… Interests: Dermatology, Rare/Orphan Diseases Reference ID: 23-T-176 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Small Molecule Splicing Modulators For Reducing Aggregatable Prion Protein In Prion Diseases First-in-class small molecules to change how the PRNP gene is spliced, reducing harmful prion levels and offering a new treatment approach for prion diseases… Interests: Neurology, Rare/Orphan Diseases, Small Molecules Reference ID: 25-T-118 Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Research Tools Therapeutics An Engineered Hypercompact CRISPR-Cas12f System with Boosted Gene-Editing Activity The engineered hypercompact enAsCas12f system addresses CRISPR-Cas systems deliverability issues while offering enhanced gene-editing high specificity making it ideal for therapeutic applications using AAV… Interests: Gene Therapy, Genomics Reference ID: 23-T-046 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics A Computational And Therapeutic Platform For Identifying And Correcting Unproductive Splicing To Restore Gene Expression Advanced computational tools to identify faulty RNA splicing events and design of antisense oligonucleotides to restore normal protein production in genetic diseases, especially those… Reference ID: 26-T-078 Desired Partnership: Co-development, Licensing IP: Patent Pending
Materials SARS-CoV-2 Therapeutics A Next-Generation mRNA Vaccine Platform For Enhancing T-Cell Responses And Improving Antiviral And Antitumor Immunity Next-generation mRNA vaccine platform uses a lipid-polymer hybrid nanoparticle to boost stability, immune cell uptake, and T cell responses, leading to stronger and longer-lasting… Interests: Biologics, Drug Delivery, Immunology, Immunotherapy, Microbiology/Virology, Oncology, Polymer, Vaccines Reference ID: 25-T-134 Desired Partnership: Co-development, Licensing IP: Patent Pending
Research Tools Therapeutics A Spatially Resolved Intracellular Photoproximity Profiling Technology For Mapping And Targeting Protein Interactions In Cancer A matched pair of photoproximity probes coupled with quantitative proteomics which enable context-dependent mapping of protein complex topology inside cells including to map MYC… Interests: Drug Development Tool, Drug Screening, Drug Target, Oncology Reference ID: 26-T-081 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics Fatty acids In T Cell-Based Cancer Therapies Enhanced anti-tumor immunity through immunomodulation is achieved by fatty acids that activate CD8+ T cells, thereby improving cancer immunotherapy efficacy and reducing T-cell exhaustion.… Interests: Oncology, Wound Healing Reference ID: 26-T-061 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics PMO-Based RNA-Degrading Chimeras For Targeted Degradation Of α-Synuclein mRNA In Neurodegenerative Diseases Phosphorodiamidate morpholino oligomer (PMO)-based RNA-degrading chimeras reduce α-synuclein protein by degrading its messenger RNA preventing protein aggregation and propagation associated with neurodegenerative diseases. The… Interests: Biologics, Drug Development Tool, Neurology, Rare/Orphan Diseases Reference ID: 26-T-051 Desired Partnership: Co-development, Licensing IP: Patent Pending
