Medical Devices Therapeutics Simultaneous Acquisition of Myocyte Oxygen Usage and Cardiac Strain Data in a Single MRI Scan Abnormal myocardial oxygen usage can predict heart attack or heart transplant rejection before the onset of clinical symptoms. However, there are currently no robust… Interests: Cardiovascular, Healthcare IT, Imaging Reference ID: 17-T-074 Desired Partnership: Licensing IP: Patent Pending
Other Therapeutics Novel Platform for Allosterically Modifying Enzyme Specificty Fine tuning enzyme specificity is desired for industrial catalysis. Enzymes lacking structural characterization or favorable recombinant expression are not amenable to traditional directed evolution… Reference ID: 14-T-118 Desired Partnership: Investment, Licensing IP: Patent Issued
Materials Medical Devices Therapeutics Doped Silicon Nanowires for the Selective Modulation of Single-cells Electric stimulation of organs with implantable devices has demonstrated clinical utility for the treatment of a variety of diseases such as cardiac arrythmia. However,… Interests: Immunotherapy, Neurology, Psychiatry Reference ID: 18-T-008 Desired Partnership: Licensing IP: Patent Pending
Therapeutics CAR T-Cells That Recognize Cancer-specific Glycopeptides Across Multiple Cancer Types The development of cancer immunotherapies is limited by a lack of targetable tumor antigens. Most currently targeted antigens have basal expression in healthy tissue,… Interests: Immunotherapy, Oncology, Oncology Solid Tumor Reference ID: 18-T-045 Desired Partnership: Co-development, Licensing IP: Patent Pending
Diagnostics Therapeutics IRDS: Predictive 7-gene Signature for Breast Cancer Therapy After surgical removal of breast cancer tumors, adjuvant chemotherapy and radiation therapy have an absolute survival benefit of just 5-10%. Currently approved breast cancer… Reference ID: 05-T-101 Desired Partnership: Licensing IP: Patent Issued
Therapeutics Novel Small Molecule Treatment for Staphylococcus Aureus SSTI Infections SUMMARY Staphylococcus aureus infects 50,000 patients and kills 20,000 annually in the United States alone. With widespread antibiotic resistance, there is an urgent need… Interests: Antibody, Biologics, Drug Screening, Infectious Disease Reference ID: 10-T-108 Desired Partnership: Co-development, Licensing IP: Patent Issued
Research Tools Therapeutics Activity-responsive Split RNA Polymerase Platform for Biosensors and Gene Therapy An understanding of protein-protein interactions (PPIs) is critical to uncovering new disease pathophysiology and for developing small molecule and antibody treatments. Problematically, current approaches… Interests: Biologics, Drug Delivery, Drug Screening, Gene Therapy Reference ID: 16-T-069 Desired Partnership: Co-development, Licensing IP: Patent Pending
Therapeutics siRNA/shRNA Therapy for the Sensitization of Treatment-resistant Solid Tumors to Chemo and Radiation Therapy Adjuvant radiation therapy post-surgery remains largely ineffective, with just 5% of patients showing a survival benefit. Small molecule JAK inhibitors have shown efficacy in… Interests: Oncology, Oncology Hematopoietic, Oncology Radiotherapy, Oncology Solid Tumor Reference ID: 12-T-099 Desired Partnership: Co-development, Licensing IP: Patent Issued
Therapeutics Synergistic Combination of Immunologic Inhibitors for the Treatment of Cancer Current immunotherapy approaches often focus on targeting a single immune checkpoint or suppressive pathway, which can be insufficient given the redundancy and adaptability of… Interests: Antibody, Biologics, Immunotherapy, Oncology, Oncology Hematopoietic, Oncology Solid Tumor Reference ID: 12-T-132 Desired Partnership: Licensing IP: Patent Issued
Medical Devices Therapeutics A Combined Therapy and Imaging Beam Dose Algorithm for Optimal Image-guided Radiation Therapy kV radiation dose for imaging tumors is useful for direct monitoring and real-time organ tracking without relying on high-risk surgical implants. However, the utility… Interests: Drug Screening, Imaging, Oncology Radiotherapy, Oncology Solid Tumor Reference ID: 14-T-016 Desired Partnership: Licensing IP: Patent Issued
Research Tools Therapeutics Depalmitoylation Chemical Probes Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and… Interests: Diabetes, Drug Delivery, Drug Screening, Hematology, Infectious Disease, Metabolic Disorders, Neurology, Oncology, Oncology Hematopoietic, Oncology Radiotherapy, Oncology Solid Tumor Reference ID: 16-T-128 Desired Partnership: Co-development, Licensing IP: Patent Issued
Diagnostics Therapeutics A Prognostic Gene Signature for Predicting Chemotherapy Sensitivity and Patient Survival in ER-negative Breast Cancer ER-negative (ER-) breast cancers make up 20% of all breast cancer diagnosis. However, no gene signature exists for predicting drug sensitivity and prognosis. Therefore,… Interests: Oncology, Oncology Solid Tumor Reference ID: 17-T-011 Desired Partnership: Co-development, Licensing IP: Patent Pending
