SUMMARY Automated microfluidic platform enabling high-throughput, precise 3D cell and organoid culture, drug screening, and single-cell analysis, allowing real-time monitoring and dynamic control of cellular environments for advanced research in cancer, stem cells, and personalized medicine. The Unmet Need: Platforms that can… Read More
SUMMARY New compounds that inhibit an enzyme to reduce hydrogen sulfide in the carotid body, helping to normalize breathing and prevent sleep apnea by targeting the underlying cause of abnormal breathing during sleep The Unmet Need: Targeted, mechanism-based treatments that can restore… Read More
SUMMARY The Unmet Need: Precise evaluation and effective treatment planning for proprioception Proprioception is a critical aspect of human motor control and balance, traditionally evaluated during neurological and physical examinations. In these fields, there is a growing recognition that qualitative assessments alone… Read More
SUMMARY The field of oncological diagnostics and therapeutics has long sought methods to refine treatment approaches for aggressive cancers. In conditions such as advanced high-grade ovarian cancer, there is a critical need for techniques that can accurately predict therapeutic responses and guide personalized treatment decisions. This is driven by the… Read More
SUMMARY Innovative therapeutic strategy leveraging commensal microbiota, specifically by oral administration of Bifidobacterium, to enhance anti-tumor immunity, potentially improving cancer treatment when combined with checkpoint inhibitors Unmet Need: Only 20-40% of patients respond to immunotherapy while a majority… Read More
SUMMARY A method to attenuate RSV and other NNS RNA viruses by reducing m6A modifications on their RNA. This approach enhances genetic stability, ensures sufficient attenuation, triggers higher immune responses, retains high immunogenicity, and makes vaccine production feasible. The problem: A live… Read More
SUMMARY Non-Hodgkin’s lymphoma is among the most common types of cancer in the US consisting of a diverse group of lymphocytic malignancies. Most of these malignancies are B-cell of which chronic lymphocytic leukemia (CLL) is one of them. CLL is a demanding disease for patients and early treatment methods have… Read More
SUMMARY Methicillin-resistant Staphylococcus aureus (MRSA) infection is the leading cause of skin and soft tissue infections that affect nearly 30% of healthy adults. Staph infections can escalate in intensity if introduced to the bloodstream and can lead to sepsis or death. The current treatment of MRSA is partially effective through oxacillin… Read More
SUMMARY Block copolymers can assemble into large-scale, dense, and regular nanoscale patterns, making block copolymer assembly a potential candidate for nanolithography. The assembly of block copolymers can be directed to follow a chemical pattern to generate a regular structure. Notwithstanding the success of existing approaches, current chemical patterning methods are… Read More
SUMMARY Sentimental analysis for financial forecasting has been impeded by the ultra-high dimensional challenge of numerically representing huge troves of text. Prior efforts circumvented this bottleneck by reusing word scoring devised for earlier studies, utilizing sentiment values imprecisely matched to context, significantly reducing the value of the results. The faculty… Read More
SUMMARY The global market size for coagulation testing is expected to grow at a CAGR of 7.7% and reach US$3.5 billion by 2027 from US$2.1 billion in year 2020. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are the most frequently performed coagulation tests with estimated annual… Read More
SUMMARY There have been significant research efforts to develop various COVID-19 treatments. Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus i.e. SARS-CoV-2, which has spread rapidly throughout the world and was declared a global pandemic by WHO in March 2020. Nsp15 is… Read More