News Tanda Biotech: Revolutionizing Bioproduction for a Sustainable Future Tanda Biotech is a participant in cohort 2 of Resurgence, a cleantech accelerator led by the University of Chicago’s Polsky Center for Entrepreneurship and Innovation in partnership with the Pritzker...
Technology A Platform for Developing High-Affinity Selective Binding Proteins to Short and Flexible Peptide Motifs Short and flexible peptide motifs such as GPCRs and histone tails are attractive targets for therapeutic development, but the generation of traditional antibodies against these targets remains a challenge because…
Technology Type I Interferons For Enhancing Chimeric Antigen Receptor T-Cell Efficacy Method to enhance CAR T-cell efficacy by incorporating low-dose exogenous IFN-α2 into CD19-directed, CD28-costimulated CAR T cells post-transduction during manufacturing boosting cytolytic molecule expression, cytokine secretion, and cytotoxicity while minimizing…
Technology Nanotraps for the containment and clearance of SARS-CoV-2 Inventors devised a nanomedicine termed “Nanotraps” that can completely capture and eliminate SARS-CoV-2 by triggering macrophages to engulf and clear the virus without becoming infected. Ex vivo lung perfusion system.…
Technology A Chimeric Antigen Coreceptor System For Optimized Antigen Targeting A novel chimeric antigen coreceptor system mimicking the CD4/CD8 and TCR interaction to enhance signaling for increased antigen sensitivity to treat B cell malignancies. The unmet need: Solutions for…
Technology A Next-Generation mRNA Vaccine Platform For Enhancing T-Cell Responses And Improving Antiviral And Antitumor Immunity Next-generation mRNA vaccine platform uses a lipid-polymer hybrid nanoparticle to boost stability, immune cell uptake, and T cell responses, leading to stronger and longer-lasting protection against viruses and cancer while…
Technology A Transcriptomic Signature Platform For Predicting Prognosis And Guiding Therapy In Ovarian Cancer Patients A 10-gene signature based on glucocorticoid receptor activity to predict survival risk in high-grade serous ovarian cancer patients, helping identify those who may benefit from specific therapies and improving personalized…
News Eight Alumni-Led Startups to Compete in 2022 ANVC Finals The Polsky Center for Entrepreneurship and Innovation is pleased to announce the eight finalist teams that will vie for investment in the 2022 Alumni New Venture Challenge (ANVC), a global competition dedicated...
News 20 Startups Accepted into Phase II of the 2024 Alumni New Venture Challenge The Polsky Center for Entrepreneurship and Innovation is pleased to announce the 20 startups accepted into the 2024 Alumni New Venture Challenge (ANVC), a global competition dedicated to supporting all University of...
News 8 Alumni-Led Startups to Compete in 2024 ANVC Finals The Polsky Center for Entrepreneurship and Innovation is pleased to announce the eight finalist teams that will vie for investment in the 2024 Alumni New Venture Challenge (ANVC), a global competition...
Technology A Spatially Resolved Intracellular Photoproximity Profiling Technology For Mapping And Targeting Protein Interactions In Cancer A matched pair of photoproximity probes coupled with quantitative proteomics which enable context-dependent mapping of protein complex topology inside cells including to map MYC interactomes across temporal, spatial and disease-relevant…
Technology A Prognostic Gene Signature for Predicting Chemotherapy Sensitivity and Patient Survival in ER-negative Breast Cancer ER-negative (ER-) breast cancers make up 20% of all breast cancer diagnosis. However, no gene signature exists for predicting drug sensitivity and prognosis. Therefore, the clinical standard remains treating patients…
